1309953-52-3Relevant articles and documents
Synthesis and structural revision of phomopsin B, a novel polyketide carrying a 10-membered cyclic-ether ring
Izuchi, Yuko,Koshino, Hiroyuki,Hongo, Yayoi,Kanomata, Nobuhiro,Takahashi, Shunya
, p. 3360 - 3363 (2011/08/22)
Total synthesis of the proposed structure 2 for phomopsin B was achieved by using an intramolecular olefin metathesis as a key step. The spectral data, however, did not match with those of the natural product reported. Re-examination of the reported NMR data led to the structural revision of phomopsin B to known dothiorelone A 18. The R configuration of dothiorelone A was determined by total synthesis through a cross-metathesis with a chiral olefin 19.