130997-64-7

Basic information

• Product Name: (2Z)-3-prop-2-en-1-yl-6-(trifluoromethoxy)-1,3-benzothiazol-2(3H)-imine hydrobromide
• CAS NO: 130997-64-7
• Molecular Formula: C₁₁H₁₀BrF₃N₂OS
• Molecular Weight: 355.1741
• Mol File: 130997-64-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 306.2°C at 760 mmHg
• Flash Point: 139°C
• Vapor Pressure: 0.000781mmHg at 25°C
• CAS DataBase Reference: (2Z)-3-prop-2-en-1-yl-6-(trifluoromethoxy)-1,3-benzothiazol-2(3H)-imine hydrobromide(CAS DataBase Reference)
• NIST Chemistry Reference: (2Z)-3-prop-2-en-1-yl-6-(trifluoromethoxy)-1,3-benzothiazol-2(3H)-imine hydrobromide(130997-64-7)
• EPA Substance Registry System: (2Z)-3-prop-2-en-1-yl-6-(trifluoromethoxy)-1,3-benzothiazol-2(3H)-imine hydrobromide(130997-64-7)

Safety Data

• Hazardous Substances Data: 130997-64-7(Hazardous Substances Data)

Usage

General Description

(2Z)-3-prop-2-en-1-yl-6-(trifluoromethoxy)-1,3-benzothiazol-2(3H)-imine hydrobromide is a chemical compound that falls under the category of organic compounds. It consists of a benzothiazolimine core with a trifluoromethoxy group and a propenyl substituent. (2Z)-3-prop-2-en-1-yl-6-(trifluoromethoxy)-1,3-benzothiazol-2(3H)-imine hydrobromide is synthesized in the form of a hydrobromide salt. It may have various applications in the field of organic chemistry, pharmaceuticals, and materials science. Additionally, it may possess certain biological activities that make it a potential candidate for drug development or other therapeutic purposes. Furthermore, it may have implications in the study and research of various biochemical and physiological processes.

Upstream product

• 461-82-5 4-(trifluoromethoxy)aniline 
• 106-95-6 allyl bromide 
• 1744-22-5 Riluzole 

Relevant articles and documents

Riluzole series. synthesis and in vivo 'antiglutamate' activity of 6- substituted-2-benzothiazolamines and 3-substituted-2-imino-benzothiazolines

Two series of analogues of riluzole, a blocker of excitatory amino acid mediated neurotransmission, have been synthesized: monosubstituted 2- benzothiazolamines and 3-substituted derivatives. Of all the compounds prepared in the first series, only 2-benzothiazolamines bearing alkyl, polyfluoroalkyl, or polyfluoroalkoxy substituents in the 6-position showed potent anticonvulsant activity against administration of glutamic acid in rats. The most active compounds displaying in vivo 'antiglutamate' activity were the 6-OCF3 (riluzole), 6-OCF2CF3, 6-CF3, and 6-CF2CF3 substituted derivatives with ED50 values between 2.5 and 3.2 mg/kg i.p. Among the second series of variously substituted benzothiazolines, compounds as active as riluzole or up to 3 times more potent were identified in two series: benzothiazolines bearing a β-dialkylaminoethyl moiety and compounds with an alkylthioalkyl chain and their corresponding sulfoxides and sulfones. The most potent derivatives were 2-imino-3-(2-methylthio)- and 2-imino-3-(2- methylsulfinyl)-ethyl-6-trifluoromethoxybenzothiazolines (61 and 64, ED50 = 1.0 and 1.1 mg/kg i.p., respectively). In addition, intraperitoneal administration of some of the best benzothiazolines protected mice from mortality produced by hypobaric hypoxia.