130997-64-7

Usage

Uses

Used in Organic Chemistry:
(2Z)-3-prop-2-en-1-yl-6-(trifluoromethoxy)-1,3-benzothiazol-2(3H)-imine hydrobromide is used as a building block or intermediate in the synthesis of more complex organic molecules, due to its unique structure and functional groups.
Used in Pharmaceutical Industry:
(2Z)-3-prop-2-en-1-yl-6-(trifluoromethoxy)-1,3-benzothiazol-2(3H)-imine hydrobromide is used as a potential candidate for drug development, as it may possess certain biological activities that can be harnessed for therapeutic purposes.
Used in Materials Science:
(2Z)-3-prop-2-en-1-yl-6-(trifluoromethoxy)-1,3-benzothiazol-2(3H)-imine hydrobromide is used in the development of new materials with specific properties, such as sensors, catalysts, or other functional materials, due to its unique chemical structure.
Used in Research and Development:
(2Z)-3-prop-2-en-1-yl-6-(trifluoromethoxy)-1,3-benzothiazol-2(3H)-imine hydrobromide is used in the study and research of various biochemical and physiological processes, as it may provide insights into the mechanisms of certain biological phenomena or help in the development of new research tools.

Upstream product

• 461-82-5 4-(trifluoromethoxy)aniline 
• 106-95-6 allyl bromide 
• 1744-22-5 Riluzole 

Relevant academic research and scientific papers

Riluzole series. synthesis and in vivo 'antiglutamate' activity of 6- substituted-2-benzothiazolamines and 3-substituted-2-imino-benzothiazolines

Two series of analogues of riluzole, a blocker of excitatory amino acid mediated neurotransmission, have been synthesized: monosubstituted 2- benzothiazolamines and 3-substituted derivatives. Of all the compounds prepared in the first series, only 2-benzothiazolamines bearing alkyl, polyfluoroalkyl, or polyfluoroalkoxy substituents in the 6-position showed potent anticonvulsant activity against administration of glutamic acid in rats. The most active compounds displaying in vivo 'antiglutamate' activity were the 6-OCF3 (riluzole), 6-OCF2CF3, 6-CF3, and 6-CF2CF3 substituted derivatives with ED50 values between 2.5 and 3.2 mg/kg i.p. Among the second series of variously substituted benzothiazolines, compounds as active as riluzole or up to 3 times more potent were identified in two series: benzothiazolines bearing a β-dialkylaminoethyl moiety and compounds with an alkylthioalkyl chain and their corresponding sulfoxides and sulfones. The most potent derivatives were 2-imino-3-(2-methylthio)- and 2-imino-3-(2- methylsulfinyl)-ethyl-6-trifluoromethoxybenzothiazolines (61 and 64, ED50 = 1.0 and 1.1 mg/kg i.p., respectively). In addition, intraperitoneal administration of some of the best benzothiazolines protected mice from mortality produced by hypobaric hypoxia.