1310031-63-0Relevant articles and documents
First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase
Mercey, Guillaume,Verdelet, Tristan,Saint-Andre, Geraldine,Gillon, Emilie,Wagner, Alain,Baati, Rachid,Jean, Ludovic,Nachon, Florian,Renard, Pierre-Yves
, p. 5295 - 5297 (2011/06/19)
Nerve agents are highly toxic organophosphorus compounds with strong inhibition potency against acetylcholinesterase (AChE). Herein, we describe two first extremely promising uncharged reactivators for poisoned human AChE with a superior or similar in vitro ability to reactivate the enzyme as compared to that of HI-6, obidoxime, TMB-4 and HLoe-7.