1235142-25-2Relevant academic research and scientific papers
Combination delivery of two oxime-loaded lipid nanoparticles: Time-dependent additive action for prolonged rat brain protection
Pashirova, Tatiana N.,Bra?ki, Anissa,Zueva, Irina V.,Petrov, Konstantin A.,Babaev, Vasily M.,Burilova, Evgenia A.,Samarkina, Darya A.,Rizvanov, Ildar Kh.,Souto, Eliana B.,Jean, Ludovic,Renard, Pierre-Yves,Masson, Patrick,Zakharova, Lucia Ya.,Sinyashin, Oleg G.
, p. 102 - 111 (2018/10/21)
A novel approach for brain protection against poisoning by organophosphorus agents is developed based on the combination treatment of dual delivery of two oximes. Pralidoxime chloride (2-PAM) and a novel reactivator, 6-(5-(6,7-dimethoxy-3,4-dihydroisoquin
Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases
Renou, Julien,Loiodice, Mélanie,Arboléas, Mélanie,Baati, Rachid,Jean, Ludovic,Nachon, Florian,Renard, Pierre-Yves
, p. 3947 - 3950 (2014/04/03)
Two promising uncharged reactivators for inhibited human BChE and AChE have been described. These compounds show an ability to reactivate VX-inhibited BChE largely superior to those of known pyridinium aldoximes. Moreover, these oximes also exhibit a good
SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
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, (2015/01/16)
The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system. (I)
SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES
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, (2015/01/16)
Disclosed are compounds of formula (I) that are useful as hepatitis C virus (HCV) NSSB polymerise inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NSSB polymerise activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
Straightforward and efficient synthesis of 3-benzyloxy-4-bromopicolinate ester and 3-benzyloxy-5-bromopicolinate ester, common building blocks for pharmaceuticals and agrochemicals
Verdelet, Tristan,Mercey, Guillaume,Correa, Nobi,Jean, Ludovic,Renard, Pierre-Yves
experimental part, p. 8757 - 8762 (2011/11/29)
A practical and rapid preparation of 3-benzyloxy-4-bromo and 3-benzyloxy-5-bromopicolinate esters 10 and 16 was developed in four steps, respectively, in 38% and 31% overall yield. Then their viability as partners for cross-coupling reactions has been evaluated in Suzuki-Miyaura, Hartwig-Buchwald, and Sonogashira reactions to synthesize biologically relevant targets. The preparation of these two highly functionalizable pyridines 10 and 16 has been never described to date in the literature and could be used as common building block for the preparation of several biologically active compounds or agrochemical products.
First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase
Mercey, Guillaume,Verdelet, Tristan,Saint-Andre, Geraldine,Gillon, Emilie,Wagner, Alain,Baati, Rachid,Jean, Ludovic,Nachon, Florian,Renard, Pierre-Yves
, p. 5295 - 5297 (2011/06/19)
Nerve agents are highly toxic organophosphorus compounds with strong inhibition potency against acetylcholinesterase (AChE). Herein, we describe two first extremely promising uncharged reactivators for poisoned human AChE with a superior or similar in vitro ability to reactivate the enzyme as compared to that of HI-6, obidoxime, TMB-4 and HLoe-7.
