1310036-86-2Relevant academic research and scientific papers
N-substituted sultam carboxylic acids as novel glycogen synthase activators
Qian, Yimin,Bolin, David R.,Conde-Knape, Karin,Gillespie, Paul,Hayden, Stuart,Huang, Kuo-Sen,Liu, Mei,Olivier, Andree R.,Ren, Yonglin,Sergi, Joseph,Xiang, Qing,Yi, Lin,Yun, Weiya,Zhang, Xiaolei
, p. 833 - 838 (2013/08/26)
Decreased glycogen synthesis and turnover is a common defect in type 2 diabetic patients. Activating glycogen synthase, the enzyme that catalyses the transfer of glucose from UDP-glucose to a glycogen polymer chain, could be a potential therapeutic target for the treatment of diabetes. We discovered a series of N-substituted sultam carboxylic acids as potent glycogen synthase activators. Treatment of human skeletal muscle cells with these compounds resulted in an increase in glycogen synthesis. Compound 4 displayed good oral bioavailability and therefore may be a useful tool molecule to study GS as a potential anti-diabetic target. The Royal Society of Chemistry 2013.
NOVEL CARBOXYLIC ACID ANALOGS AS GLYCOGEN SYNTHASE ACTIVATORS
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, (2011/06/24)
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
