1310048-95-3

Basic information

• Product Name: 2-(3-fluorobenzyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane
• Synonyms: 2-(3-fluorobenzyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane;3-Fluorophenylmethylboronic acid pinacol ester;2-(3-Fluorobenzyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane(WX658004)
• CAS NO: 1310048-95-3
• Molecular Formula: C₁₃H₁₈BFO₂
• Molecular Weight: 236.0902232
• Mol File: 1310048-95-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 269.4±23.0 °C(Predicted)
• Appearance: /
• Density: 1.04±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: 2-(3-fluorobenzyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-fluorobenzyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane(1310048-95-3)
• EPA Substance Registry System: 2-(3-fluorobenzyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane(1310048-95-3)

Safety Data

• Hazardous Substances Data: 1310048-95-3(Hazardous Substances Data)

Usage

General Description

2-(3-fluorobenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, also known as 2-(3-fluorobenzyl)-pinacol boronate, is a chemical compound commonly used in organic synthesis and medicinal chemistry. It is a boron-containing reagent with a boronate ester functional group, making it a useful precursor for the synthesis of various biologically active molecules and pharmaceuticals. 2-(3-fluorobenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane has been utilized in the development of drugs for the treatment of cancer, infectious diseases, and other medical conditions. Its unique structure and versatility make it a valuable building block for the creation of new chemical entities, as well as a tool for investigating biological processes and drug discovery research.

Upstream product

• 1073-06-9 3-fluorobromobenzene 
• 78782-17-9 4,4,5,5-tetramethyl-2-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]-1,3,2-dioxaborolane 
• 456-47-3 3-fluoro-benzenemethanol 
• 73183-34-3 bis(pinacol)diborane 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 
• 57606-65-2 m-fluorophenyl trifluoromethanesulfonate 

Downstream Products

• 1373432-88-2 C₂₇H₂₈FN₃O₃ 

Relevant articles and documents

Regioselective α-benzylation of 3-iodoazetidine via Suzuki cross-coupling

An efficient protocol for the synthesis of α-benzyl azetidines starting from benzylboronic acid pinacol ester derivatives and 3-iodoazetidine was developed. A wide range of α-benzyl azetidine derivatives were obtained in moderate to good yields with high regioselectivity (>99%).

Synthesis of Benzyl-, Allyl-, and Allenyl-boronates via Copper-Catalyzed Borylation of Alcohols

Alcohols are among the most abundant and readily available organic feedstocks in industrial processes. The direct catalytic functionalization of sp3 C-O bonds of alcohols remains the main challenge in this field. Here, we report a copper-cataly

Chemoselective Suzuki coupling of diborylmethane for facile synthesis of benzylboronates

The chemoselective Pd-catalyzed Suzuki-Miyaura cross-coupling reaction using a diborylmethane is reported. The use of an equimolar amount of base with a diborylmethane realized chemoselective coupling for the synthesis of various benzylboronate derivatives. Sterically hindered aryl bromides can give products in moderate to excellent yields.