1310048-95-3

Usage

Uses

Used in Pharmaceutical Industry:
2-(3-fluorobenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is used as a synthetic intermediate for the development of drugs targeting cancer, infectious diseases, and other medical conditions. Its boronate ester functional group allows for the creation of complex molecular structures with potential therapeutic properties.
Used in Organic Synthesis:
In the field of organic synthesis, 2-(3-fluorobenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane serves as a key building block for constructing a variety of chemical compounds. Its reactivity and stability make it suitable for use in various synthetic pathways, facilitating the formation of desired products with high yields and selectivity.
Used in Medicinal Chemistry Research:
2-(3-fluorobenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is employed as a research tool in medicinal chemistry to investigate biological processes and discover new drug candidates. Its unique structure allows for the exploration of novel chemical space and the identification of potential therapeutic agents with improved efficacy and selectivity.

Upstream product

• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 
• 73183-34-3 bis(pinacol)diborane 
• 456-47-3 3-fluoro-benzenemethanol 
• 57606-65-2 m-fluorophenyl trifluoromethanesulfonate 
• 78782-17-9 4,4,5,5-tetramethyl-2-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]-1,3,2-dioxaborolane 
• 1073-06-9 3-fluorobromobenzene 

Downstream Products

• 1373432-88-2 C₂₇H₂₈FN₃O₃ 

Relevant academic research and scientific papers

Regioselective α-benzylation of 3-iodoazetidine via Suzuki cross-coupling

An efficient protocol for the synthesis of α-benzyl azetidines starting from benzylboronic acid pinacol ester derivatives and 3-iodoazetidine was developed. A wide range of α-benzyl azetidine derivatives were obtained in moderate to good yields with high regioselectivity (>99%).

Isoquinolone compound and application thereof

The invention relates to an isoquinolone compound and application thereof. The invention in particular relates to an isoquinolone compound used as a HIF prolyl hydroxylase inhibitor (HIF-PHI) and a pharmaceutical composition thereof. Moreover, the present invention provides the application of the isoquinolinone compound or the pharmaceutical composition thereof in the preparation of a medicament for preventing or treating HIF-associated or HIF-mediated diseases as anemia or ischemia, local ischemia or hypoxia.

Synthesis of Benzyl-, Allyl-, and Allenyl-boronates via Copper-Catalyzed Borylation of Alcohols

Alcohols are among the most abundant and readily available organic feedstocks in industrial processes. The direct catalytic functionalization of sp3 C-O bonds of alcohols remains the main challenge in this field. Here, we report a copper-cataly

Pd-catalyzed cross-coupling of 1,1-diborylalkanes with aryl triflates

The Pd-catalyzed synthesis of benzylboronic esters through coupling of aryl triflates with 1,1-diborylalkane under ambient conditions is described. Varieties of primary and secondary arylboronic esters could be successfully synthesized by this strategy. C

Chemoselective Suzuki coupling of diborylmethane for facile synthesis of benzylboronates

The chemoselective Pd-catalyzed Suzuki-Miyaura cross-coupling reaction using a diborylmethane is reported. The use of an equimolar amount of base with a diborylmethane realized chemoselective coupling for the synthesis of various benzylboronate derivatives. Sterically hindered aryl bromides can give products in moderate to excellent yields.