1310056-89-3

Upstream product

• 717919-06-7 5-benzyloxy-4-benzyloxymethyl-pentane-1,2-diol 
• 142754-53-8 C₂₀H₂₄O₂ 
• 99776-34-8 4-benzyloxy-3-benzyloxymethylbutyraldehyde 
• 108-24-7 acetic anhydride 
• 717919-08-9 4-benzyloxy-3-benzyloxymethyl-1-(4,5-dihydro-furan-2-yl)-butan-1-ol 
• 42201-43-4 2-allyl-1,3-propanediol 
• 2049-80-1 (2-propenyl)propanedioic acid diethyl ester 

Downstream Products

• 717919-10-3 4-Benzyloxy-3-benzyloxymethyl-1-{2-[(2E,4E)-7-(tert-butyl-dimethyl-silanyloxy)-4-methyl-hepta-2,4-dienyloxy]-tetrahydro-furan-2-yl}-butan-1-ol 
• 717918-96-2 4-Benzyloxy-3-benzyloxymethyl-1-{2-[(2E,4E)-7-(tert-butyl-dimethyl-silanyloxy)-4-methyl-hepta-2,4-dienyloxy]-tetrahydro-furan-2-yl}-butan-1-one 
• 1310056-96-2 C₃₉H₅₈O₇Si 

Relevant academic research and scientific papers

A cyclic acetal tethered intramolecular diels-alder cycloaddition. studies directed toward a total synthesis of (±)-fusidilactone C

Efforts toward a synthesis of (±)-fusidilactone C is described here featuring a novel cyclic acetal tethered intramolecular Diels-Alder strategy. This unique and facile IMDA turned out to be highly endo-selective [endo-I and endo-II], as assessed from our mechanistic analyses. When using protic solvents or Lewis acids, the endo-I selectivity was greatly enhanced. Thus, it proved to be a real challenge to circumvent this excellent stereochemical outcome, which is undesired for the total synthesis, as an exo-II selectivity is desired. Progress was made to use the endo-II cycloadduct and to access the desired trans-2-oxadecalin motif in (±)-fusidilactone C. The Japan Institute of Heterocyclic Chemistry.