131019-87-9

Usage

Uses

Used in Hair Dye Industry:
N'-Methyl-4-Methylbenzene-1,2-diaMine is used as a key ingredient in hair dyes for its coloring properties. It contributes to the formation of the desired color in hair dyes, providing a wide range of color options for consumers.
Used in Coloring Products Industry:
In addition to hair dyes, N'-Methyl-4-Methylbenzene-1,2-diaMine is also utilized in the production of other coloring products, such as pigments and dyes for various applications. Its ability to impart color makes it a valuable component in these industries.
Safety Precautions:
Due to its toxic and potentially harmful nature, it is crucial to take proper precautions when handling N'-Methyl-4-Methylbenzene-1,2-diaMine. This includes the use of protective equipment, such as gloves, masks, and goggles, to minimize skin and respiratory exposure. Additionally, adhering to safety protocols and guidelines is essential to ensure the well-being of individuals working with this chemical.

Upstream product

• 65081-42-7 3-(N-methylamino)-4-nitrotoluene 
• 106-49-0 p-toluidine 
• 854639-67-1 toluene-4-sulfonic acid-(5,N-dimethyl-2-nitro-anilide) 
• 343617-23-2 toluene-4-sulfonic acid-(5-methyl-2-nitro-anilide) 
• 578-46-1 5-methyl-2-nitroaniline 
• 537-92-8 3-Methylacetanilide 
• 446-34-4 2-fluoro-4-methyl-1-nitrobenzene 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 616-38-6 carbonic acid dimethyl ester 
• 7732-18-5 water 

Downstream Products

• 857616-83-2 acetic acid-(4-methyl-2-methylamino-anilide) 
• 77314-27-3 2-(4-Chloro-phenyl)-1,6-dimethyl-1H-benzoimidazole 
• 77314-26-2 2-(4-Methoxy-phenyl)-1,6-dimethyl-1H-benzoimidazole 
• 690231-90-4 2-chloro-N-(4-methyl-2-methylamino-phenyl)-5-nitro-benzamide 
• 1191924-15-8 C₂₂H₁₉Cl₂N₅ 
• 77314-24-0 1,6-Dimethyl-2-p-tolyl-1H-benzoimidazole 

Relevant academic research and scientific papers

Cu-Catalyzed C-H Allylation of Benzimidazoles with Allenes

CuH-catalyzed intramolecular cyclization and intermolecular allylation of benzimidazoles with allenes have been described. The reaction proceeded smoothly with the catalytic system of Cu(OAc)2/Xantphos and catalytic amount of (MeO)2MeSiH. This protocol features mild reaction conditions and a good tolerance of substrates bearing electron-withdrawing, electron-donating, or electron-neutral groups. A new catalytic mechanism was proposed for this copper hydride catalytic system.

Linear free energy substitutent effect on flavin redox chemistry

A systematic study on the effect of various substituents at the 7- and/or 8-position on the redox properties of isoalloxazines (flavins) is reported. The redox properties of these flavin derivatives were studied by cyclic voltammetry in 100 mM, pH 7.4 HEPES and 200 mM, pH 10 borate buffers. The magnitude and direction of the effect was dependent on the nature and location of the substituent. The redox potentials of the substituted flavins were correlated with the Hammett σ value of the substituents.

Regioselective Radical Arene Amination for the Concise Synthesis ofortho-Phenylenediamines

The formation of arene C-N bonds directly from C-H bonds is of great importance and there has been rapid recent development of methods for achieving this through radical mechanisms, often involving reactiveN-centered radicals. A major challenge associated with these advances is that of regiocontrol, with mixtures of regioisomeric products obtained in most protocols, limiting broader utility. We have designed a system that utilizes attractive noncovalent interactions between an anionic substrate and an incoming radical cation in order to guide the latter to the areneorthoposition. The anionic substrate takes the form of a sulfamate-protected aniline and telescoped cleavage of the sulfamate group after amination leads directly toortho-phenylenediamines, key building blocks for a range of medicinally relevant diazoles. Our method can deliver both free amines and monoalkyl amines allowing access to unsymmetrical, selectively monoalkylated benzimidazoles and benzotriazoles. As well as providing concise access to valuableortho-phenylenediamines, this work demonstrates the potential for utilizing noncovalent interactions to control positional selectivity in radical reactions.

Discovery of 2-iminobenzimidazoles as potent hepatitis C virus inhibitors with a novel mechanism of action

In this report we describe 2-iminobenzimidazole (IBI) analogs, identified during the course of a phenotypic high-throughput screening campaign, as novel hepatitis C virus (HCV) inhibitors. A series of IBI derivatives was synthesized and evaluated for their inhibitory activity against infectious HCV. Among the IBIs derivatives studied in this work, we identified promising compounds with high antiviral efficacy, high selectivity index and good microsomal stability. Noteworthy, the IBI series exhibited inhibitory activity on early and late steps of the viral cycle, but not in the HCV replicon system demonstrating a mechanism of action distinct from clinical-stage and approved anti-HCV drugs. Overall, our results suggest that IBIs are predestinated for further exploration as lead compounds for novel HCV interventions.

BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R0, R1, R2, R3/sup

BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R0, R1, R2, R3/sup

Bicyclic Benzimidazole Compounds and Their Use as Metabotropic Glutamate Receptor Potentiators

Compounds of Formula I: wherein A, B, D, L, R1, R2, R3, R4, m, and n are as defined for Formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.

Discovery of small molecule benzimidazole antagonists of the chemokine receptor CXCR3

High-throughput screening identified a low molecular weight antagonist of CXCR3 displaying micromolar activity in a membrane filtration-binding assay. Systematic modification of the benzimidazole core and tethered acetophenone moiety established tractable SAR of analogs with improved physicochemical properties and sub-micromolar activity across both human and murine receptors.

BENZIMIDAZOLE DERIVATIVES

The present invention relates to a compound of the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1,R2, R3, R4, R5, A, X, n, and are as defined herein. Such novel benzamidazole derivatives are useful in trv treatment of abnormal cell growth, such as cancer, in mammals. This invention ate relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing sue compounds.

Highly selective zeolite-catalysed mono-N-alkylation of arylenediamines by dialkyl carbonates

Arylenediamines are mono-N-alkylated by dialkyl carbonates in the presence of NaY zeolite catalyst in a regioselective and nontoxic process.