131019-87-9

Basic information

• Product Name: N'-Methyl-4-Methylbenzene-1,2-diaMine
• Synonyms: N'-Methyl-4-Methylbenzene-1,2-diaMine;N1,5-DiMethylbenzene-1,2-diaMine;4,N*2*-Dimethyl-benzene-1,2-diamine;N2,4-dimethyl-1,2-benzenediamine
• CAS NO: 131019-87-9
• Molecular Formula: C₈H₁₂N₂
• Molecular Weight: 136.19428
• Mol File: 131019-87-9.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: N'-Methyl-4-Methylbenzene-1,2-diaMine(CAS DataBase Reference)
• NIST Chemistry Reference: N'-Methyl-4-Methylbenzene-1,2-diaMine(131019-87-9)
• EPA Substance Registry System: N'-Methyl-4-Methylbenzene-1,2-diaMine(131019-87-9)

Safety Data

• Hazardous Substances Data: 131019-87-9(Hazardous Substances Data)

Usage

General Description

N'-Methyl-4-Methylbenzene-1,2-diaMine, also known as N,N'-dimethyl-1,2-phenylenediamine, is an organic compound primarily used in the production of hair dyes and other coloring products. It is a derivative of benzene-1,2-diamine, containing two methyl substituents on the amino groups. This chemical is classified as a skin irritant and sensitizer, and is listed as a potential human carcinogen. Due to its toxic and potentially harmful nature, proper precautions should be taken when handling N'-Methyl-4-Methylbenzene-1,2-diaMine, including the use of protective equipment and adherence to safety protocols.

Upstream product

• 106-49-0 p-toluidine 
• 854639-67-1 toluene-4-sulfonic acid-(5,N-dimethyl-2-nitro-anilide) 
• 578-46-1 5-methyl-2-nitroaniline 
• 446-34-4 2-fluoro-4-methyl-1-nitrobenzene 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 616-38-6 carbonic acid dimethyl ester 
• 7732-18-5 water 
• 65081-42-7 3-(N-methylamino)-4-nitrotoluene 
• 537-92-8 3-Methylacetanilide 
• 343617-23-2 toluene-4-sulfonic acid-(5-methyl-2-nitro-anilide) 

Downstream Products

• 857616-83-2 acetic acid-(4-methyl-2-methylamino-anilide) 
• 77314-24-0 1,6-Dimethyl-2-p-tolyl-1H-benzoimidazole 
• 10394-40-8 1,6-dimethylbenzimidazole 

Relevant articles and documents

Cu-Catalyzed C-H Allylation of Benzimidazoles with Allenes

CuH-catalyzed intramolecular cyclization and intermolecular allylation of benzimidazoles with allenes have been described. The reaction proceeded smoothly with the catalytic system of Cu(OAc)2/Xantphos and catalytic amount of (MeO)2MeSiH. This protocol features mild reaction conditions and a good tolerance of substrates bearing electron-withdrawing, electron-donating, or electron-neutral groups. A new catalytic mechanism was proposed for this copper hydride catalytic system.

Regioselective Radical Arene Amination for the Concise Synthesis ofortho-Phenylenediamines

The formation of arene C-N bonds directly from C-H bonds is of great importance and there has been rapid recent development of methods for achieving this through radical mechanisms, often involving reactiveN-centered radicals. A major challenge associated with these advances is that of regiocontrol, with mixtures of regioisomeric products obtained in most protocols, limiting broader utility. We have designed a system that utilizes attractive noncovalent interactions between an anionic substrate and an incoming radical cation in order to guide the latter to the areneorthoposition. The anionic substrate takes the form of a sulfamate-protected aniline and telescoped cleavage of the sulfamate group after amination leads directly toortho-phenylenediamines, key building blocks for a range of medicinally relevant diazoles. Our method can deliver both free amines and monoalkyl amines allowing access to unsymmetrical, selectively monoalkylated benzimidazoles and benzotriazoles. As well as providing concise access to valuableortho-phenylenediamines, this work demonstrates the potential for utilizing noncovalent interactions to control positional selectivity in radical reactions.

BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R0, R1, R2, R3/sup