131035-57-9

Upstream product

• 63435-16-5 3-hydroxy-4-aminobenzoic acid methyl ester 
• 407-25-0 trifluoroacetic anhydride 
• 20442-96-0 methyl 4-azidobenzoate 
• 76-05-1 trifluoroacetic acid 
• 619-45-4 4-methoxycarbonyl aniline 
• 713-52-0 methyl 3-hydroxy-4-nitrobenzoate 

Downstream Products

• 131035-58-0 Methyl 3-hydroxy-2-nitro-4-N-trifluoroacetylaminobenzoate 
• 131035-59-1 Methyl 2-amino-3-hydroxy-4-N-trifluoroacetylaminobenzoate 

Relevant academic research and scientific papers

C-H oxygenation and N-trifluoroacylation of arylamines under metal-free conditions: A convenient approach to 2-aminophenols and N-trifluoroacyl-ortho- aminophenols

Direct ortho-hydroxylation through C-H oxygenation and N-trifluoroacylation of anilines was achieved in a single step under metal-free conditions by using a combination of TFA and oxone. The method allowed the formation of functionalised amino phenolic compounds such as ortho-hydroxy-N- trifluoroacetanilides in good yields with broad substrate scope.

SEMI-SYNTHESIS OF A.23187 (CALCIMYCIN) ANALOGS WITH 5-N-AMINO SUBSTITUENTS. THEIR COMPLEXATION OF CALCIUM AND MAGNESIUM

The semi-synthesis of A.23187 (calcimycin) analogs 1-4 bearing the respective substituents: 5-NH2, 5-NHCH3, 5-N(CH3)2, 5-NHCOCH3 was carried out.The complexing properties of 1-4 for calcium and magnesium were determined by two-phase experiments (water/toluene-butanol 70:30 W:W) and found to be much weaker than these of A.23187 or X.14885A.There was a discrepancy with theoretical predictions made from model carboxybenzoxazoles.