1310357-22-2Relevant academic research and scientific papers
Synthesis of key fragments of leiodelide A
Chellat, Mathieu F.,Proust, Nicolas,Lauer, Matthew G.,Stambuli, James P.
supporting information; experimental part, p. 3246 - 3249 (2011/08/22)
The synthesis of all key fragments of the marine macrolide leiodelide A is described. The polyoxygenated northern subunit is derived from d-xylose, while the southern subunit is rapidly assembled via an aldol reaction and Horner-Wadsworth-Emmons olefination. This highly convergent approach will allow for rapid modification and assembly of several isomers of leiodelide A, which may be necessary considering the assignment of leiodelide B has been previously shown to be incorrect.
