1310406-77-9

Upstream product

• 6626-15-9 4-Bromoresorcinol 
• 55583-11-4 2,4-dibenzyloxybromobenzene 
• 1310406-76-8 tert-butyl 4-(2,4-dihydroxyphenyl)piperidine-1-carboxylate 
• 1310406-75-7 tert-butyl 4-(2,4-bisbenzyloxyphenyl)-4-hydroxy-piperidine-1-carboxylate 
• 108-46-3 recorcinol 
• 401565-73-9 C₁₃H₁₉NO₂ 
• 41979-39-9 4-piperidone hydrochloride 
• 151-10-0 1,3-Dimethoxybenzene 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 

Downstream Products

• 1310406-58-6 4-(1-phenylmethanesulphonylpiperidin-4-yl)-benzene-1,3-diol 
• 1228342-28-6 (S)-4-(2,4-dihydroxyphenyl)-N-(1-phenylethyl)-piperidine-1-carboxamide 

Relevant academic research and scientific papers

Process Development and Good Manufacturing Practice Production of a Tyrosinase Inhibitor via Titanium-Mediated Coupling between Unprotected Resorcinols and Ketones

A concise and economically attractive process for the synthesis of a novel tyrosinase inhibitor has been developed and implemented on a multikilogram scale under GMP. A major achievement to the success of the process is the development of a direct coupling between free resorcinol and ketone. First developed under basic conditions, this coupling has been turned to a novel titanium(IV) mediated process allowing good selectivity, easy isolation, and high atom efficiency. Other key steps feature an alkene reduction by palladium catalyzed transfer hydrogenation and a urea formation using N,N′-disuccinimidyl carbonate as the carbonyl source. This route allowed us to produce kilogram batches of the candidate to support preclinical and clinical studies.

4-piperidin-4-yl-benzene -1,3-diol and synthesis of the salt, and new compd. tert-butyl 4 - (2,4-dihydroxy-phenyl) - 4-hydroxy-piperidin-1-hydroxyphenylalkanecarboxylate

A method is described for the synthesis of 4-piperidin-4-yl-benzene-1,3-diol of the following formula (I): and the pharmaceutically acceptable salts thereof. Also described, is tert-butyl 4-(2,4-dihydroxy-phenyl)-4-hydroxy-piperidine-1-carboxylate as a no

METHOD FOR THE SYNTHESISING 4-PIPERIDIN-4-YL-BENZENE-1,3-DIOL AND THE SALTS OF SAME AND NOVEL COMPOUND TERT-BUTYL 4-(2,4-DIHYDROXY-PHENYL)-4-HYDROXY-PIPERIDINE-1-CARBOXYLATE

A method is described for the synthesis of 4-piperidin-4-yl-benzene-1,3-diol of the following formula (I): and the pharmaceutically acceptable salts thereof. Also described, is tert-butyl 4-(2,4-dihydroxy-phenyl)-4-hydroxy-piperidine-1-carboxylate as a no

4- (AZACYCLOALKYL) -BENZENE-1, 3 -DIOL DERIVATIVES AS TYROSINASE INHIBITORS AND THEIR SYNTHESIS AND USE THEREOF

The present invention concerns novel 4-(azacycloalkyl)-benzene-1,3-diol compounds with the following general formula (I): to compositions containing them, to a process for their preparation and to their use in pharmaceutical or cosmetic compositions for t