1310409-76-7Relevant academic research and scientific papers
Discovery of small molecule human FPR1 receptor antagonists
Unitt, John,Fagura, Malbinder,Phillips, Tim,King, Sarah,Perry, Matthew,Morley, Andrew,MacDonald, Cathy,Weaver, Richard,Christie, Jadeen,Barber, Simon,Mohammed, Rukhsana,Paul, Melanie,Cook, Andrew,Baxter, Andrew
scheme or table, p. 2991 - 2997 (2011/06/24)
The identification of two novel series of formyl peptide receptor 1 (FPR1) antagonists are reported, represented by methionine benzimidazole 6 and diamide 7. Both series specifically inhibited the binding of labelled fMLF to hrFPR1 and selectively antagonized FPR1 function in human neutrophils, making them useful in vitro validation tools for the target.
