1204-75-7

Basic information

• Product Name: 3-HYDROXY-2-QUINOXALINECARBOXYLIC ACID
• Synonyms: TIMTEC-BB SBB003659;3-HYDROXY-2-QUINOXALINECARBOXYLIC ACID;3-hydroxyquinoxaline-2-carboxylic acid;3-HYDROXY-2-QUINOXALINECARBOXYLIC ACID 98%;3,4-Dihydro-3-oxoquinoxaline-2-carboxylic acid;3-Hydroxy-2-quinoxalinecarboxylic acid,98%;3-hydroxyquinoxaline-2-carboxylic acid(SALTDATA: FREE);3-Hydroxy-2-quinoxalinecarboxylic acid, 98% 5GR
• CAS NO: 1204-75-7
• Molecular Formula: C₉H₆N₂O₃
• Molecular Weight: 190.16
• EINECS: 214-877-4
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Quinoxalines
• Mol File: 1204-75-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 267-268 °C(lit.)
• Boiling Point: 325.64°C (rough estimate)
• Flash Point: 215.3 °C
• Appearance: Green-yellow/Powder and Chunks
• Density: 1.3907 (rough estimate)
• Refractive Index: 1.5570 (estimate)
• CAS DataBase Reference: 3-HYDROXY-2-QUINOXALINECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-HYDROXY-2-QUINOXALINECARBOXYLIC ACID(1204-75-7)
• EPA Substance Registry System: 3-HYDROXY-2-QUINOXALINECARBOXYLIC ACID(1204-75-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 1204-75-7(Hazardous Substances Data)

Usage

Chemical Properties

green-yellow powder and chunks

Uses

3-Hydroxy-2-quinoxalinecarboxylic acid was used to study the sorption of ionizable organic compounds to an estuarine sediment. It was used in the preparation of Zinc(II)-quinoxaline complexes which was characterized by X-ray crystallography and fluorescence spectroscopy.

Biochem/physiol Actions

3-Hydroxy-2-quinoxalinecarboxylic acid is an antagonist of excitatory amino acids and possesses anticonvulsant properties. It inhibits the 22Na+ efflux produced in 22Na+-preloaded brain slices by N-methyl-D-aspartate and kainate.

InChI:InChI=1/C9H6N2O3/c12-8-7(9(13)14)10-5-3-1-2-4-6(5)11-8/h1-4H,(H,11,12)(H,13,14)/p-1

Upstream product

• 473-90-5 acetonedicarboxylic acid 
• 39145-59-0 o-phenylenediamine hydrochloride 
• 99185-73-6 3-oxo-3,4-dihydro-quinoxaline-2-carboxylic acid methylamide 
• 36818-07-2 ethyl 3-oxo-4H-quinoxaline-2-carboxylate 
• 490-59-5 alloxazine 
• 81225-99-2 1,5-Dihydro-2H-1,5-benzodiazepin-2,3,4-trione hydrate 
• 49568-68-5 3-chloroquinoxaline-2-carboxaldehyde 
• 54107-98-1 3-benzenesulfonyloxyalloxazine 
• 110307-58-9 anhydro-1-hydroxy-3-methyl-4-(methoxycarbonyl)-s-triazolo<4,3-a>quinoxalinium hydroxide 
• 110307-56-7 1-methyl-3-benzenesulfonyloxyalloxazine 
• 110307-62-5 C₁₁H₁₀N₆O₂ 
• 95-54-5 1,2-diamino-benzene 
• 49679-55-2 ethyl 3-ethoxyquinoxaline-2-carboxylate 
• 81225-96-9 3-<(Butylamino)methylen>-1,5-dihydro-2H-1,5-benzodiazepin-2,4(3H)-dion 

Downstream Products

• 15804-19-0 quinoxaline-2,3-dione 
• 36818-07-2 ethyl-3-hydroxy-quinoxaline-2-carboxylate 
• 49679-41-6 3-chloroquinoxaline-2-carbonyl chloride 
• 1189548-04-6 N-{(1S)-2-[4-(4-chlorophenoxy)piperidin-1-yl]-1-methyl-2-oxoethyl}-3-hydroxyquinoxaline-2-carboxamide 
• 1189548-05-7 N-{(1S)-2-[4-(4-fluorophenoxy)piperidin-1-yl]-1-methyl-2-oxoethyl}-3-hydroxyquinoxaline-2-carboxamide 
• 1189548-06-8 N-{(1S)-2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-1-methyl-2-oxoethyl}-3-hydroxyquinoxaline-2-carboxamide 
• 1189548-08-0 N-{(1S)-2-[4-(4-cyanophenoxy)piperidin-1-yl]-1-methyl-2-oxoethyl}-3-hydroxyquinoxaline-2-carboxamide 
• 1189548-10-4 N-[(1S)-1-{[4-(4-chlorophenoxy)piperidin-1-yl]carbonyl}propyl]-3-hydroxyquinoxaline-2-carboxamide 
• 1189548-15-9 N-[(1S)-1-{[4-(2,4-difluorophenoxy)piperidin-1-yl]carbonyl}propyl]-3-hydroxyquinoxaline-2-carboxamide 
• 1189548-17-1 N-[(1S)-1-{[4-(4-cyanophenoxy)piperidin-1-yl]carbonyl}propyl]-3-hydroxyquinoxaline-2-carboxamide 
• 1189548-21-7 N-{(1S)-1-cyclopropyl-2-[4-(4-fluorophenoxy)piperidin-1-yl]-2-oxoethyl}-3-hydroxyquinoxaline-2-carboxamide 
• 1189548-23-9 N-[(1S)-1-{[4-(4-chlorophenoxy)piperidin-1-yl]carbonyl}-2-methylpropyl]-3-hydroxyquinoxaline-2-carboxamide 
• 1189548-26-2 N-[(1R)-1-{[4-(4-Fluorophenoxy)piperidin-1-yl]carbonyl}-2-methylpropyl]-3-hydroxyquinoxaline-2-carboxamide 
• 1189548-33-1 N-[(1S)-1-{[4-(2,4-difluorophenoxy)piperidin-1-yl]carbonyl}-2-methylpropyl]-3-hydroxyquinoxaline-2-carboxamide 

Related news

Phosphorescence of a ruthenium(II) hydride-carbonyl complex with 3-HYDROXY-2-QUINOXALINECARBOXYLIC ACID (cas 1204-75-7) as a co-ligand07/21/2019

The [RuH(CO)(hqxc)(PPh3)2] complex, where hqxc is 3-hydroxy-2-quinoxalinecarboxylate, exhibits strong phosphorescence (quantum yield F = 0.0078) in the solid state giving rise to a significantly Stokes-shifted spectrum (excitation at 484 nm and emission at 687 nm); the lifetime of 6.5 μs is ver...detailed

A study of the molecular structure and spectroscopic properties of 3-HYDROXY-2-QUINOXALINECARBOXYLIC ACID (cas 1204-75-7) by experimental methods and quantum chemical calculations07/18/2019

The mid-IR and Raman spectra of 3-hydroxy-2-quinoxalinecarboxylic acid (3HQC) were recorded. These spectra were interpreted with the help of B3LYP/6-311++G(d,p) calculations and potential energy distribution (PED) analysis. As a result of the calculations, seven tautomers were determined among m...detailed

Relevant articles and documents

Permanganate Oxidation of Quinoxaline and Its Derivatives

The oxidation reaction of a series of quinoxaline derivatives, using KMnO4 in the presence or absence of NaOH, are described.Neutral oxidation of 2-chloro- and 2,3-dichlorodioxalines 2-4 afforded the corresponding chloro- and dichloropyrazinedicarboxilic acids 13 and 14 in good yield.On the other hand, oxidation of quinoxalin-2(1H)-one and 1,4-dihydroquinoxaline-2,3-dione derivatives in alkaline medium gave different products, with the quinoxalin-2(1H)-one (5) forming 1,4-dihydroquinoxaline-2,3-dione (9), while various substituted quinoxalin-2,3-dione derivatives (see 9-11) gave a new type of dimeric products.The structural assignments for the new compounds were based on spectroscopic data.

COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNOMEDIATED INFLAMMATORY DISORDERS

Compositions and methods for the prevention and treatment of immunomediated inflammatory disorders, especially for those disorders associated with the respiratory tract, are provided. More particularly, a tryptase inhibitor, typically a hydroxyaroyl or hydroxyheteroaroyl substituted dipeptide, is administered. Also provided by this invention are pharmaceutical compositions, typically aerosol or topical, as well as aerosol devices for administering these compositions intranasally.

A Comparison of Nucleophilic Reactions of 3-Benzenesulfonyloxyalloxazine and its 1-Methyl Analog.

Reactions of 3-benzenesulfonyloxyalloxazine (1a) and its 1-methyl analog 1b with a number of nucleophilic reagents are reported.Relatively small nucleophiles, such as hydroxide ion, methanol, ethanol, methylamine, hydrazine and hydroxylamine converted 1a to 4-carboxy-s-triazoloquinoxalin-1(2H)-ones and the corresponding esters or amides.As the size of the amine increased from methylamine to ethylamine, dimethylamine, propylamine and isopropylamine, there were obtained 4-(carboxamido)-s-triazoloquinoxalin-1(2H)-ones, (1-carboxamido)imidazoloquinoxalines and 2,3-bis(ureido)quinoxalines.Sodium hydride or potassium cyanide in hot DMF degraded 1a to imidazoloquinoxaline.However, methylmercaptide and benzylmercaptide ions attacked the sulfonate group of 1a to form 3-hydroxyalloxazine. 1-Methyl-3-benzenesulfonyloxyalloxazine (1b) reacted with methanol, ethanol, 1-propanol, and to some degree 2-propanol, in the presence of triethylamine to furnish anhydro-1-hydroxy-3-methyl-4-(alkoxycarbonyl)-s-triazoloquinoxalinium hydroxides.However, sodium methoxide in methanol converted this starting material to a mixture of anhydro-1-hydroxy-3-methyl-s-triazoloquinoxalinium hydroxide and 1-methyl-3-hydroxyflavazole.A saturated aqueous solution of triethylamine transformed 1b to anhydro-1-hydroxy-3-methyl-s-triazoloquinoxalinium hydroxide, apparently via the corresponding unstable 4-carboxylic acid.The reactions of 1b with a number of aliphatic amines yielded either amides based on the above mesionic system or on the 3-carboxamido-2-quinoxalyl semicarbazide structure.The reaction of 1b with potassium cyanide furnished 1-methylimidazoloquinoxaline.Mechanisms to explain all of the degradations are advanced.