1310412-60-2

Basic information

• Product Name: BenzaMide, N-(tetrahydro-2H-pyran-3-yl)-, (3R)-
• Synonyms: BenzaMide, N-(tetrahydro-2H-pyran-3-yl)-, (3R)-
• CAS NO: 1310412-60-2
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.253
• Mol File: 1310412-60-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BenzaMide, N-(tetrahydro-2H-pyran-3-yl)-, (3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzaMide, N-(tetrahydro-2H-pyran-3-yl)-, (3R)-(1310412-60-2)
• EPA Substance Registry System: BenzaMide, N-(tetrahydro-2H-pyran-3-yl)-, (3R)-(1310412-60-2)

Safety Data

• Hazardous Substances Data: 1310412-60-2(Hazardous Substances Data)

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 1310412-42-0 1-benzoylamino-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester 
• 613-94-5 benzoic acid hydrazide 
• 98-88-4 benzoyl chloride 

Relevant articles and documents

Direct Access to Primary Amines from Alkenes by Selective Metal-Free Hydroamination

Direct and selective synthesis of primary amines from easily available precursors is attractive yet challenging. Herein, we report the rapid synthesis of primary amines from alkenes via metal-free regioselective hydroamination at room temperature. Ammonium carbonate was used as ammonia surrogate for the first time, allowing for efficient conversion of terminal and internal alkenes into linear, α-branched, and α-tertiary primary amines under mild conditions. This method provides a straightforward and powerful approach to a wide spectrum of advanced, highly functionalized primary amines which are of particular interest in pharmaceutical chemistry and other areas.

Radical-transfer hydroamination of olefins with N-aminated dihydropyridines

An efficient synthesis of N-phthalimidyl, benzamidyl, acetamidyl, carbamoyl, and ureayl derivatives of dihydropyridines and the application of these reagents as precursors for N-centered radicals are presented. These aminated dihydropyridines could be used in radical-transfer hydroamination reactions of various electron-rich as well as nonactivated olefins in the presence of thiols as polarity-reversal catalysts. These reactions worked without the aid of any transition metal. Steric and electronic effects exerted by the N-substitutents of the N-centered radicals are discussed. In contrast to most metal-catalyzed processes, the radical hydroamination delivered the opposite regioisomer with excellent anti-Markovnikov selectivity. Hydroamination products were obtained as protected amines that are readily isolated. Festival of amination: We have presented an efficient synthesis of N-phthalimidyl, benzamidyl, acetamidyl, carbamoyl, and ureayl derivatives of dihydropyridines and the application of these reagents as precursors for N-centered radicals (see scheme). These aminated dihydropyridines can be used in radical-transfer hydroamination reactions.