1310429-65-2Relevant academic research and scientific papers
Synthesis, characterization and cytotoxic effect of ring-substituted and ansa-bridged vanadocene complexes
Honzí?ek, Jan,Klepalová, Iva,Vinklárek, Jaromír,Padělková, Zdeňka,Císa?ová, Ivana,?iman, Pavel,?ezá?ová, Martina
, p. 1 - 7 (2011)
The cytotoxic effect of vanadocene dichloride (Cp2VCl 2, 1) and its ring-substituted, (η5-C 5H4Me)2VCl2 (2), (η5-C5Me5)2VCl2 (3), (η5-C5H4R)2VCl2 (4: R = MeOCH2CH2-, 5: R = 2-MeOC6H 4CH2-, 6: R = 4-MeOC6H4CH 2-) and ansa-bridged analogs Me2C(η5-C 5H4)2VCl2 (7) and Me 4C2(η5-C5H4) 2VCl2 (8) was investigated. Synthesis of two new methoxy-functionalized compounds (4 and 5) is described. They were characterized by spectroscopic methods and X-ray diffraction analysis. The cytotoxicity studies were performed with leukemic cells MOLT-4.
