131058-39-4Relevant academic research and scientific papers
Structure-activity relationship of indoloquinoline analogs anti-MRSA
Zhao, Min,Kamada, Tomonori,Takeuchi, Aya,Nishioka, Hiromi,Kuroda, Teruo,Takeuchi, Yasuo
, p. 5551 - 5554 (2015/11/17)
Indolo[3,2-b]quinoline analogs (3a-3s), 4-(acridin-9-ylamino) phenol hydrochloride (4), benzofuro[3,2-b]quinoline (3t), indeno[1,2-b]quinolines (3u and 3v) have been synthesized. Those compounds were found to exhibit anti-bacterial activity towards Methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship studies were conducted that indoloquinoline ring, benzofuroquinoline ring and 4-aminophenol group are essential structure for anti-MRSA activity.
Bis-alkylamine indolo[3,2- B ]quinolines as hemozoin ligands: Implications for antimalarial cytostatic and cytocidal activities
Paulo, Alexandra,Figueiras, Marta,MacHado, Marta,Charneira, Catarina,Lavrado, Jo?o,Santos, Sofia A.,Lopes, Dinora,Gut, Jiri,Rosenthal, Philip J.,Nogueira, Fátima,Moreira, Rui
, p. 3295 - 3313 (2014/05/20)
To get insight into the relevance of targeting hemozoin (Hz) crystals, two isomeric series, N5,N10-bis-alkylamine (2a-k) and N10,O11-bis-alkylamine (3a-k) indolo[3,2-b]quinolines, were evaluated for their in vitro activity against chloroquine (CQ)-resista
Synthesis and antitumor activity of fused quinoline derivatives. V. Methylindolo[3,2-b]quinolines
Takeuchi, Yasuo,Kitaomo, Masayuki,Chang, Ming-Rong,Shirasaka, Shota,Shimamura, Chinami,Okuno, Yumiko,Yamato, Masatoshi,Harayama, Takashi
, p. 2096 - 2099 (2007/10/03)
Indolo[3,2-b]quinoline derivatives (1b-i) with a methyl group at each possible position have been synthesized. The 1-methyl (1b) and 9-methyl (1i) derivatives were inactive, but the 3-methyl (1d), 4-methyl (1e), and 6- methyl (1f) derivatives exhibited high treatment/control (T/C) value and cure rates against leukemia P388 in mice. These results indicated that modification of indolo[3,2-b]quinoline derivatives at 3, 4, and 6 positions may be useful approach for lead optimization.
Condensed quinoline system N-glycosides
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, (2008/06/13)
The present invention provides condensed quinoline compounds represented by the following general formula (I): STR1 in which Z is NH, X is hydrogen, L is lower alkoxy, M is NHQ, Q is --SO2 CH3, Y is --NHR, and R is: STR2 These compounds are effective for inhibiting KB-cell growth and prolongation of the life span of mice implanted with tumor P-388.
SYNTHESIS OF 7-SUBSTITUTED INDOLOQUINOLINE DERIVATIVES
Chang, Ming-rong,Takeuchi, Yasuo,Hashigaki, Kuniko,Yamato, Masatoshi
, p. 147 - 152 (2007/10/02)
Indoloquinoline derivatives (7b-j> having the substituent, such as a nitro, amino, methyl, halogen, methoxy, or hydroxy group were prepared by three methods.
