131070-57-0Relevant articles and documents
Palladium-catalyzed sequential alkylation-alkenylation reactions: Application towards the synthesis of polyfunctionalized fused aromatic rings
Alberico, Dino,Paquin, Jean-Fran?ois,Lautens, Mark
, p. 6283 - 6297 (2007/10/03)
The synthesis of polyfunctionalized fused aromatic carbo- and heterocycles from aryl iodides and bromoenoates via a tandem palladium-catalyzed aromatic substitution intramolecular Heck sequence is reported. Using Pd(OAc)2 and tri-2-furylphosphine (TFP) in the presence of norbornene and Cs 2CO3 in CH3CN at 85°C gave a variety of functionalized bi- and tricyclic fused aromatic rings in good yield.
Multiple pathways in rhodium-catalyzed reactions of 1-alkynes with 3-butenoic acid
Salerno, Giuseppe,Panza, Maria,Chiusoli, Gian Paolo,Costa, Mirco
, p. 569 - 581 (2007/10/02)
Rhodium(I) complexes have been shown to catalyze the reaction of 1-alkynes with 3-butenoic acid in alcoholic solvents at 85 deg C.Various pathways, involving rhodium-bonded vinylidene, α-vinyl, β-vinyl or alkynyl group as intermediates, have been uncovered under slightly different conditions.The stereo- and regiochemisty of these reactions provide evidence for the intermediacy of vinylidene-rhodium complexes when tertiary phosphine ligands are used.Subsequent protonation leads to β-vinylrhodium complexes.In contrast, α-vinylrhodium intermediates are involved in the case of di- or tri-alkyl or -aryl-phosphite ligands.The latter ligands also favour the formation of alkynylrhodium complexes at lower temperatures.Some mechanistic aspects are discussed.
