1310709-06-8Relevant articles and documents
Rhodium-catalyzed regioselective direct C-H arylation of indoles with aryl boronic acids
Wang, Liang,Qu, Xing,Li, Zhan,Peng, Wang-Ming
supporting information, p. 3754 - 3757 (2015/06/08)
A highly efficient Rh(III)-catalyzed direct C-H arylation of indoles with aryl boronic acids under mild conditions has been developed. The methodology features wide substrate scope and excellent functional group compatibility (34 examples, up to 99% yield). The arylated products can also be conveniently transformed into biologically active polycyclic indole derivatives.
Ru-catalysed C-H arylation of indoles and pyrroles with boronic acids: Scope and mechanistic studies
Sollert, Carina,Devaraj, Karthik,Orthaber, Andreas,Gates, Paul J.,Pilarski, Lukasz T.
supporting information, p. 5380 - 5386 (2015/03/30)
The Ru-catalysed C2-H arylation of indoles and pyrroles by using boronic acids under oxidative conditions is reported. This reaction can be applied to tryptophan derivatives and tolerates a wide range of functional groups on both coupling partners, including bromides and iodides, which can be further derivatised selectively. New indole-based ruthenacyclic complexes are described and investigated as possible intermediates in the reaction. Mechanistic studies suggest the on-cycle intermediates do not possess a para-cymene ligand and that the on-cycle metalation occurs through an electrophilic attack by the Ru centre. High tolerance: An oxidative, Ru-catalysed, and highly selective C-H arylation of indoles and pyrroles is accomplished by using boronic acids (see picture; pym=2-pyrimidyl). The reaction tolerates a wide range of functional groups, including aryl iodides and tryptophan derivatives. New indole-based ruthenacycles are described and their role in the mechanism is investigated.
Ruthenium-catalyzed direct C-H bond arylations of heteroarenes
Ackermann, Lutz,Lygin, Alexander V.
supporting information; experimental part, p. 3332 - 3335 (2011/09/12)
Ruthenium-catalyzed C-H bond arylations of indoles, thiophenes, and pyrroles were accomplished in a highly chemo- and site-selective manner through the use of removable directing groups.
