131072-60-1

Upstream product

• 36679-81-9 4-hydroxymethyl-1,2,3,4-tetrahydrofuran-2-one 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 5472-38-8 diethyl 2-formylbutanedioate 
• 105-13-5 4-Methoxybenzyl alcohol 

Downstream Products

• 131072-61-2 Methyl 4-(4-methoxy-benzyloxy-methyl)-2-oxo-tetrahydrofuran-3-carboxylate 
• 530098-82-9 3-hydroxymethyl-4-(4-methoxy-benzyloxy)-N,N-dimethyl-butyramide 
• 1309477-60-8 3-acetyl-4-((4-methoxybenzyloxy)methyl)dihydrofuran-2(3H)-one 
• 1309477-61-9 (E)-1-(4-(4-methoxybenzyloxymethyl)-2-oxodihydrofuran-3(2H)-ylidene)ethyl dimethyl phosphate 

Relevant academic research and scientific papers

The first total synthesis of (±)-cyclophostin and (±)-cyclipostin P: Inhibitors of the serine hydrolases acetyl cholinesterase and hormone sensitive lipase

Cyclophostin, a structurally unique and potent naturally occurring acetyl cholinesterase (AChE) inhibitor, and its unnatural diastereomer were prepared in 6 steps and 15% overall yield from hydroxymethyl butyrolactone. The unnatural diastereomer of cyclop

Five membered ring formation of 2-hydroxyalkyl malonate and acetoacetate derivatives the problem of O-versus C-alkylation

The cyclization reactions of type 32, 34, 36, 37/38 compounds have been studied with the aim of achieving a carbon-carbon bond forming reaction at C-2 of optically active glycerol derivatives as indicated in Scheme 1. In all cases O-alkylation at the proximal CO group has been observed.