1310862-15-7Relevant academic research and scientific papers
Enantioselective Synthesis of 3-Substituted 3-Amino-2-oxindoles by Amination with Anilines
Yang, Wenkun,Dong, Pei,Xu, Jian,Yang, Jian,Liu, Xiaohua,Feng, Xiaoming
supporting information, p. 9272 - 9275 (2021/06/01)
A chiral N,N′-dioxide-nickel(II) complex-catalyzed asymmetric amination of 3-bromo-3-substituted oxindoles with anilines has been developed. A series of alkyl or aryl 3-amino-indolinones with quaternary stereocenters were obtained in high yields with excellent ee values in one step (up to 99 % yield, up to 96 % ee). The method provided a ready route to optically active intermediates of 3-amino-2-oxindole-based bioactive compounds. Moreover, a possible transition-state model is proposed so as to elucidate the origin of the chirality based on the X-ray crystal structure of the catalyst and the adduct.
Synthesis of enantiomerically enriched 3-amino-2-oxindoles through a palladium-mediated asymmetric intramolecular arylation of α-ketimino amides
Tolstoy, Paeivi,Lee, Samantha X. Y.,Sparr, Christof,Ley, Steven V.
, p. 4810 - 4813,4 (2012/12/12)
A highly efficient and enantioselective synthesis of 3-amino-2-oxindoles through a palladium-catalyzed asymmetric intramolecular arylation of R-ketimino amides using (R)-DiFluorPhos as the coordinating ligand is reported. This report constitutes the first
Synthesis of enantiomerically enriched 3-amino-2-oxindoles through a palladium-mediated asymmetric intramolecular arylation of α-ketimino amides
Tolstoy, P?ivi,Lee, Samantha X.Y.,Sparr, Christof,Ley, Steven V.
, p. 4810 - 4813 (2013/01/15)
A highly efficient and enantioselective synthesis of 3-amino-2-oxindoles through a palladium-catalyzed asymmetric intramolecular arylation of R-ketimino amides using (R)-DiFluorPhos as the coordinating ligand is reported. This report constitutes the first
Facile and efficient enantioselective hydroxyamination reaction: Synthesis of 3-hydroxyamino-2-oxindoles using nitrosoarenes
Shen, Ke,Liu, Xiaohua,Wang, Gang,Lin, Lili,Feng, Xiaoming
, p. 4684 - 4688 (2011/06/22)
Sc takes action: The highly enantioselective hydroxyamination reaction of N-unprotected 2-oxindoles with nitrosoarenes has been realized using the Sc(OTf)3/L1 complex. The catalyst system exhibited remarkably broad substrate scope and high effi
