131106-70-2

Basic information

• Product Name: 6-TRIFLUOROMETHYLBENZOTHIAZOLE
• Synonyms: 6-TRIFLUOROMETHYLBENZOTHIAZOLE;Benzothiazole, 6-(trifluoromethyl)- (9CI);6-(TrifluoroMethyl)benzo[d]thiazole
• CAS NO: 131106-70-2
• Molecular Formula: C₈H₄F₃NS
• Molecular Weight: 203.18
• Product Categories: BENZOTHIAZOLE
• Mol File: 131106-70-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 42 °C
• Boiling Point: 236.1±35.0 °C(Predicted)
• Appearance: /
• Density: 1.453±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -0.57±0.10(Predicted)
• CAS DataBase Reference: 6-TRIFLUOROMETHYLBENZOTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-TRIFLUOROMETHYLBENZOTHIAZOLE(131106-70-2)
• EPA Substance Registry System: 6-TRIFLUOROMETHYLBENZOTHIAZOLE(131106-70-2)

Safety Data

• Hazardous Substances Data: 131106-70-2(Hazardous Substances Data)

Usage

General Description

6-Trifluoromethylbenzothiazole is a chemical compound with the molecular formula C8H5F3NS. It is a benzothiazole derivative with a trifluoromethyl group attached to the benzene ring, making it a highly fluorinated organic compound. 6-Trifluoromethylbenzothiazole is used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is known for its diverse biological and pharmacological activities, such as antimicrobial, antifungal, and antitumor properties. Additionally, this chemical has potential applications in the field of materials science, particularly in the development of high-performance polymers and functional materials. Although its exact uses and applications are still under research and development, 6-Trifluoromethylbenzothiazole shows promise as a valuable building block for various industries.

Upstream product

• 777-12-8 2-amino-6-trifluoromethyl-1,3-benzothiazole 
• 455-14-1 4-trifluoromethylphenylamine 
• 110-46-3 isopentyl nitrite 
• 95-16-9 1,3-Benzothiazole 
• 421-83-0 trifluoromethane sulfonyl chloride 

Downstream Products

• 96232-04-1 2-amino-5-trifluoromethylbenzenethiol hydrochloride 
• 943447-83-4 6-trifluoromethyl-2-benzothiazolyltriphenylsilane 
• 1314518-69-8 C₅₄H₅₀F₆N₆O₂S₂ 
• 1314518-77-8 C₅₄H₄₈B₂F₁₀N₆O₂S₂ 
• 86691-07-8 2-amino-5-(trifluoromethyl)benzenethiol 
• 1300105-94-5 2-phenylthio-6-trifluoromethyl-1,3-benzothiazole 
• 611-70-1 phenyl isopropyl ketone 

Relevant articles and documents

Photoelectrochemical cross-dehydrogenative coupling of benzothiazoles with strong aliphatic C-H bonds

A photoelectrochemical strategy for the cross-dehydrogenative coupling of unactivated aliphatic hydrogen donors (e.g.alkanes) with benzothiazoles is reported. We used tetrabutylammonium decatungstate as the photocatalyst to activate strong C(sp3)-H bonds in the chosen substrates, while electrochemistry scavenged the extra electrons.

2-AMINOPYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF

The disclosure provides an aminopyrimidine derivative for preventing and treating diseases related to IDH mutation, a preparation method and use thereof. Specifically, the disclosure provides a compound of Formula I, a stereoisomer, racemate thereof, or pharmaceutically acceptable salt thereof. The compound of the general Formula I has isocitrate dehydrogenase 1 (IDH1) inhibitory activity and can treat cancer induced by IDH1 mutation.

Cathodic C-H Trifluoromethylation of Arenes and Heteroarenes Enabled by an in Situ-Generated Triflyltriethylammonium Complex

While several trifluoromethylation reactions involving the electrochemical generation of CF3 radicals via anodic oxidation have been reported, the alternative cathodic, reductive radical generation has remained elusive. Herein, the first cathodic trifluoromethylation of arenes and heteroarenes is reported. The method is based on the electrochemical reduction of an unstable triflyltriethylammonium complex generated in situ from inexpensive triflyl chloride and triethylamine, which produces CF3 radicals that are trapped by the arenes on the cathode surface.