1311147-20-2Relevant academic research and scientific papers
Nickel(0)-catalyzed cyclization of N -benzoylaminals for isoindolinone synthesis
Shacklady-Mcatee, Danielle M.,Dasgupta, Srimoyee,Watson, Mary P.
, p. 3490 - 3493 (2011/09/12)
A nickel(0) catalyst effectively mediates the cyclization of N-benzoyl aminals in the presence of a stoichiometric Lewis acid. This method enables preparation of a variety of isoindolinones with substitution on the benzoyl fragment and C-3 carbon. This reaction likely proceeds via an α-amidoalkylnickel(II) intermediate, which then may cyclize via either an electrophilic aromatic substitution or an insertion pathway.
