1311171-11-5Relevant articles and documents
A novel Zn2+ complex as the ratiometric two-photon fluorescent probe for biological Cd2+ detection
Ye, Weipeng,Wang, Shuxing,Meng, Xiangming,Feng, Yan,Sheng, Hongting,Shao, Zonglong,Zhu, Manzhou,Guo, Qingxiang
, p. 30 - 37 (2013/11/06)
A novel Zn2+ complex as the ratiometric two-photon fluorescent probe (HQZn) for Cd2+ detection was synthesized. Fluorescence emission spectra of the probe showed a large red-shift (75 nm) and obvious enhancement of fluorescent intensity upon the addition of Cd2+. HQZn shows high selectivity for Cd2+ over other metal ions, and can eliminate the interference of Zn2+ during Cd2+ detection. Maldi-TOF MS spectra indicated that the response of HQZn to Cd2+ was caused by central metal displacement. Cell cytotoxicity and bio-imaging studies revealed that HQZn was cell-permeable and it could be used to detect intracellular Cd2+ with low cytotoxicity under two-photon excitation.
A novel quinoline-based two-photon fluorescent probe for detecting Cd 2+in vitro and in vivo
Li, Yiming,Chong, Hanbao,Meng, Xiangming,Wang, Shuxin,Zhu, Manzhou,Guo, Qingxiang
, p. 6189 - 6194 (2012/06/15)
A new two-photon fluorescent Cd2+ probe APQ is developed by introducing a N1,N1-dimethyl-N2-(pyridin-2- ylmethyl)ethane-1,2-diamine binding group and a 4-methoxyphenylvinyl conjugation-enhancing group to the 2- and 6-positions of quinoline. This probe shows a large red shift and good emission enhancement under Cd2+ binding. It also exhibits a high ion selectivity for Cd2+ (especially over Zn2+) and a large two-photon absorption cross section at 710 nm. Two-photon microscopy imaging studies reveal that the new probe is non-toxic and cell-permeable and can be used to detect intracellular Cd2+ under two-photon excitation.