131118-85-9

Basic information

• Product Name: {(2S,4aS,6S,7S,8S,8aR)-8-Hydroxy-6-[(5R,5aS,8aS,9S)-9-(4-hydroxy-3,5-dimethoxy-phenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yloxy]-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl}-carbamic acid benzyl ester
• CAS NO: 131118-85-9
• Molecular Weight: 721.715
• Mol File: 131118-85-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: {(2S,4aS,6S,7S,8S,8aR)-8-Hydroxy-6-[(5R,5aS,8aS,9S)-9-(4-hydroxy-3,5-dimethoxy-phenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yloxy]-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl}-carbamic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {(2S,4aS,6S,7S,8S,8aR)-8-Hydroxy-6-[(5R,5aS,8aS,9S)-9-(4-hydroxy-3,5-dimethoxy-phenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yloxy]-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl}-carbamic acid benzyl ester(131118-85-9)
• EPA Substance Registry System: {(2S,4aS,6S,7S,8S,8aR)-8-Hydroxy-6-[(5R,5aS,8aS,9S)-9-(4-hydroxy-3,5-dimethoxy-phenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yloxy]-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl}-carbamic acid benzyl ester(131118-85-9)

Safety Data

• Hazardous Substances Data: 131118-85-9(Hazardous Substances Data)

Upstream product

• 92206-82-1 Chloro-acetic acid 4-((5S,5aS,9R)-9-hydroxy-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester 
• 3006-58-4 2-benzyloxycarbonylamido-2-deoxy-L-glucopyranose 
• 477-47-4 (+/-)-podophyllotoxin 
• 6559-91-7 (+/-)-4'-O-demethyl-1-epipodophyllotoxin 
• 112146-51-7 C₄₁H₄₁Cl₂NO₁₆ 
• 3006-58-4 2-carbobenzyloxyamino-2-deoxy-D-glucopyranose 
• 112146-51-7 1-O-(2-benzyloxycarbonylamido-3-chloroacetyl-2-deoxy-4:6-O-ethylidene-β-D-glucopyranosyl)-<(+)-4'-O-chloroacetyl-1-epipodophyllotoxin> 
• 112146-51-7 C₄₁H₄₁Cl₂NO₁₆ 
• 112146-51-7 1-O-(2-benzyloxycarbonylamido-3-chloroacetyl-2-deoxy-4:6-O-ethylidene-β-D-glucopyranosyl)-<(-)-4'-O-chloroacetyl-1-epipodophyllotoxin> 
• 112146-44-8 2-benzyloxycarbonylamino-3-O-chloroacetyl-2-deoxy-4,6-O-ethylidene-αβ-D-glucopyranose 
• 92206-82-1 4'-O-chloroacetyl-4'-O-demethyl-4-epipodophyllotoxin 
• 112146-51-7 4-O-(2-benzyloxycarbonylamino-3-O-chloroacetyl-2-deoxy-4,6-O-ethylidene-β-D-glucopyranosyl)-4'-O-chloroacetyl-4'-O-demethyl-4-epipodophyllotoxin 

Downstream Products

• 112146-42-6 4′-demethyl-(epi)-podophyllotoxin 4-O-2″-deoxy-2″-amino-4″,6″-di-O-ethylidene-β-D-glucopyranoside 
• 112246-51-2 1-O-(2-amino-2-deoxy-β-L-glucopyranosyl)-<(-)-1-epipodophyllotoxin> 
• 112318-79-3 1-O-(2-amino-2-deoxy-β-D-glucopyranosyl)-<(+)-1-epipodophyllotoxin> 
• 112317-52-9 1-O-(2-amino-2-deoxy-β-L-glucopyranosyl)-<(+)-1-epipodophyllotoxin> 
• 105655-99-0 1-O-(2-deoxy-2-dimethylamino-β-L-glucopyranosyl)-<(+)-1-epipodophyllotoxin> 
• 105655-99-0 1-O-(2-deoxy-2-dimethylamino-β-D-glucopyranosyl)-<(+)-1-epipodophyllotoxin> 
• 105655-99-0 1-O-(2-deoxy-2-dimethylamino-β-L-glucopyranosyl)-<(-)-1-epipodophyllotoxin> 
• 105655-99-0 1-O-(2-deoxy-2-dimethylamino-β-D-glucopyranosyl)-<(-)-1-epipodophyllotoxin> 

Relevant articles and documents

Etoposide: a new approach to the synthesis of 4-O-(2-amino-2-deoxy-4,6-O-ethylidene-β-D-glucopyranosyl)-4'-O-demethyl-4-epipodophyllotoxin

Synthesis of 3-O-acetyl-2-benzyloxycarbonylamino-2-deoxy-4,6-O-ethylidene-α-(7α) and -β-D-glucopyranose (7β) and their 3-O-chloroacetyl analogues (11α and 11β) are described.Condensation (BF3-etherate, ethyl acetate, -20 deg C) of 7α with 4'-O-benzyloxyca