1311202-93-3

Upstream product

• 187401-45-2 5-chloro-6-isopropoxynicotinic acid 
• 1311202-56-8 tert-butyl trans-3-[3-chloro-4-(N'-hydroxycarbamimidoyl)phenoxy]cyclobutanecarboxylate 
• 939768-64-6 tert-butyl (1s,3s)-3-hydroxycyclobutane-1-carboxylate 

Downstream Products

• 1311231-54-5 trans-3-[3-chloro-4-{5-(5-chloro-6-isopropoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl}phenoxy]cyclobutanecarboxylic acid 

Relevant academic research and scientific papers

Development of a scalable synthesis of oxadiazole based S1P1 receptor agonists

A robust and scalable synthesis was developed for the preparation of oxadiazole based S1P1 inhibitors. A new method for the separation of triphenylphosphine oxide from reaction products and an improved method for the synthesis of oxadiazoles in the presence of DBU were incorporated into the process to achieve its scalability.

PROCESS FOR THE PREPARATION OF 1,2,4-OXADIAZOL-3-YL DERIVATIVES OF CARBOXYLIC ACID

The present invention discloses processes for the preparation and isolation of [1,2,4]oxadiazo-3-yl derivatives of carboxylic acids. The derivatives are useful in the treatment of inflammatory diseases and conditions.