1311205-16-9Relevant academic research and scientific papers
Copper-catalyzed direct C-H oxidative trifluoromethylation of heteroarenes
Chu, Lingling,Qing, Feng-Ling
, p. 1298 - 1304 (2012)
This article describes the copper-catalyzed oxidative trifluoromethylation of heteroarenes and highly electron-deficient arenes with CF 3SiMe3 through direct C-H activation. In the presence of catalyst Cu(OAc)2, ligand 1,10-phenanthroline and cobases tert-BuONa/NaOAc, oxidative trifluoromethylation of 1,3,4-oxadiazoles with CF3SiMe3 proceeded smoothly using either air or di-tert-butyl peroxide as an oxidant to give the corresponding trifluoromethylated 1,3,4-oxadiazoles in high yields. Di-tert-butyl peroxide was chosen as the suitable oxidant for oxidative trifluoromethylation of 1,3-azoles and perfluoroarenes. Cu(OH)2 and Ag2CO3 were the best catalyst and oxidant for direct oxidative trifluoromethyaltion of indoles. The optimum reaction conditions enable oxidative trifluoromethylation of a range of heteroarenes that bear numerous functional groups. The prepared trifluoromethylated heteroarenes are of importance in the areas of pharmaceuticals and agrochemicals. The preliminary mechanistic studies of these oxidative trifluoromethylations are also reported.
Palladium-catalyzed oxidative trifluoromethylation of indoles at room Temperature
Mu, Xin,Chen, Shujun,Zhen, Xingliang,Liu, Guosheng
supporting information; experimental part, p. 6039 - 6042 (2011/06/22)
Incorporation of fluorine atoms into organic molecules significantly enhances many of their properties, such as solubility, metabolic stability, and bioavailability. Among organofluorine molecules, trifluoro ACHTUNGTRENUNGmethylated compounds play a unique and important role in agricultural and medicinal chemistry.[2] As a consequence, the exploitation of efficient methods to construct C-CF3 bond has received much attention.
