1311230-64-4

Basic information

• Product Name: 2-(3,5-difluorophenyl)tetrahydrofuran
• Synonyms: 2-(3,5-difluorophenyl)tetrahydrofuran
• CAS NO: 1311230-64-4
• Molecular Weight: 184.186
• Mol File: 1311230-64-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(3,5-difluorophenyl)tetrahydrofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,5-difluorophenyl)tetrahydrofuran(1311230-64-4)
• EPA Substance Registry System: 2-(3,5-difluorophenyl)tetrahydrofuran(1311230-64-4)

Safety Data

• Hazardous Substances Data: 1311230-64-4(Hazardous Substances Data)

Upstream product

• 109-99-9 tetrahydrofuran 
• 461-96-1 3,5-difluorobromobenzene 

Relevant articles and documents

New method for C-H arylation/alkylation at α-position of cyclic aliphatic ethers by iron-oxide mediated reaction

We report a new and efficient iron oxide catalyzed cross-coupling reaction between organometallic species such as alkyl/arylmagnesium halides or organolithium species and α-hydrogen bearing cyclic unbranched and branched aliphatic ethers via activation of C(sp3)-H. In the presence of 1 mol% of iron oxide, five and six membered unbranched cyclic ethers such as tetrahydrofuran and tetrahydropyran gave good to excellent yields of cross-coupled products. Whereas, in case of branched ether such as 2-methyltetrahydrofuran, it was observed that the arylation occurred at both the sides and gave moderate yields of a mixture of regioisomers. Among the organometallic species used, alkyl organometallic reagents gave less yields as compared to aryl organometallics.