1311293-10-3

Upstream product

• 915237-87-5 tetrahydro-2-[[3-(2-bromophenyl)-2-propyn-1-yl]oxy]-2H-pyran 
• 6089-04-9 3-(tetrahydropyran-2'-yloxy)propyne 
• 36239-09-5 ethyl chlorocarbonylacetate 
• 457071-61-3 4-{2-[3-(tetrahydro-pyran-2-yloxy)-prop-1-ynyl]-phenyl}-but-3-ynylamine 
• 457071-58-8 4-{2-[3-(tetrahydro-pyran-2-yloxy)-prop-1-ynyl]-phenyl}-but-3-yn-1-ol 
• 457071-60-2 2-{3-[2-(4-azido-but-1-ynyl)-phenyl]-prop-2-ynyloxy}-tetrahydro-pyran 
• 457071-59-9 methanesulfonic acid 4-{2-[3-(tetrahydro-pyran-2-yloxy)-prop-1-ynyl]-phenyl}-but-3-ynyl ester 
• 583-53-9 2,3-dibromobenzene 

Downstream Products

• 1311293-14-7 C₂₄H₂₁NO₃S 
• 1311293-11-4 C₁₈H₁₉NO₄ 
• 1311293-12-5 C₁₈H₁₇NO₄ 

Relevant academic research and scientific papers

Design, synthesis and inhibition activity of a novel cyclic enediyne amino acid conjugates against MPtpA

In course of studies towards the discovery of selective inhibitors of MPtpA, a novel cyclic endiyne malonamic acid has been designed and synthesized. The synthesis involves a crucial intramolecular Knoevenagel reaction. The compound displayed a reversible non-competitive inhibition against MPtpA with inhibition constant Ki of 22.5 μM. The enediyne acts as a recognition framework in inducing the inhibition and not as a reactive functional moiety. This was confirmed by comparing the inhibiting activity with that of the corresponding saturated cyclic non-enediyne analogue.