1311296-99-7

Upstream product

• 250285-32-6 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride 
• 74663-75-5 1,2-bis(2,6-diisopropylphenylimino)ethane 
• 64-19-7 acetic acid 
• 24544-04-5 2,6-diisopropylbenzenamine 

Downstream Products

• 1311297-12-7 1,3-bis(2,6-diisopropylphenyl)-1H-imidazole-2(3H)-thione 

Relevant academic research and scientific papers

Synthesis, Antitumor Activity, and Docking Study of 1,3-Disubstituted Imidazolium Derivatives

A series of 1,3-disubstituted imidazolium salts were synthesized through a convenient synthetic approach based on the reaction of 1,4-diazabuta-1,3-dienes with HClO4. Their antitumor activity was evaluated in vitro against a number of human cancer cells. 1,3-Bis[(3,5-bis(trifluoromethyl)phenyl]imidazolium perchlorate turned out to be the most active against A549 and MCF-7 cancer cell lines with IC50 values of 5.24 and 4.21 μM, respectively. The results of structure–activity relationship study indicated that substituents on the imidazole derivatives play an important role in their cytotoxic activities. Finally, molecular docking of some tested compounds was carried out in order to investigate their binding pattern with the CDK2.

Revelation from the Reaction of 1,4-Diazabutadiene with Perchloric Acid: An Approach to the Synthesis of Imidazolium Perchlorates

The reactions of 1,4-diazabutadienes 1 with HClO4were studied in detail. The final products obtained were not the hydroperchlorates of 1 but imidazolium perchlorates 2 or 3. A possible reaction process is postulated on the basis of the isolation of the intermediate 2-iminomethylimidazolium salt 4. The factors influencing the conversion of 4 to the imidazolium perchlorates 2 and 3 were discussed with regard to the electronic and steric effects of the N-substituents. This reaction can serve as an approach for the synthesis of imidazolium derivatives.

Insight into the role of the counteranion of an imidazolium salt in organocatalysis: A combined experimental and computational study

N-Heterocyclic carbenes (NHCs) can serve as very reactive nucleophilic catalysts and exhibit strong basicity. Herein, we initiate a combined experimental and computational investigation of the NHC-catalyzed ring-closing reactions of 4-(2-formylphenoxy)but