131148-65-7Relevant academic research and scientific papers
The Chiral Synthesis of Thiazole Amino Acid Enantiomers
Bredenkamp, Martin W.,Holzapfel, Cedric W.,Zyl, Wynand J. van
, p. 2235 - 2249 (2007/10/02)
An efficient modified Hantzsch reaction is described for the synthesis of optically pure thiazole amino acid derivatives from the corresponding amino acids.The method is exemplified by the synthesis of a derivative of L-(Gln)Thz, the novel chiral thiazole amino acid moiety of dolastatin 3.The Cotton effects of thiazole amino acids correlate well with the absolute stereochemistry of these compounds.
