13117-60-7 Usage
Uses
Used in Pharmaceutical Industry:
Monobutyryl cyclic AMP is used as a signaling molecule for modulating cellular processes. It is involved in the regulation of various cellular functions, including cell growth, differentiation, and apoptosis. Due to its role in these processes, it has potential applications in the development of therapeutic strategies for various diseases.
Used in Research Applications:
Monobutyryl cyclic AMP is used as a research tool for studying the role of cAMP in cellular signaling pathways. It can be employed to investigate the effects of cAMP on gene expression, protein synthesis, and other cellular processes. This helps researchers understand the underlying mechanisms of various diseases and develop targeted therapies.
Used in Drug Delivery Systems:
Monobutyryl cyclic AMP can be used in drug delivery systems to improve the bioavailability and efficacy of therapeutic agents. By incorporating it into drug delivery vehicles, such as nanoparticles or liposomes, it may enhance the delivery of drugs to specific target cells, reducing side effects and increasing the therapeutic potential of the treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 13117-60-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,1,1 and 7 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 13117-60:
(7*1)+(6*3)+(5*1)+(4*1)+(3*7)+(2*6)+(1*0)=67
67 % 10 = 7
So 13117-60-7 is a valid CAS Registry Number.
InChI:InChI=1/C14H18N5O7P/c1-2-3-8(20)18-12-9-13(16-5-15-12)19(6-17-9)14-10(21)11-7(25-14)4-24-27(22,23)26-11/h5-7,10-11,14,21H,2-4H2,1H3,(H,22,23)(H,15,16,18,20)/t7-,10-,11-,14-/m1/s1
13117-60-7Relevant academic research and scientific papers
Membrane-permeable octanoyloxybenzyl-masked cNMPs as novel tools for non-invasive cell assays
Ruthenbeck, Alexandra,Marangoni, Elisa,Diercks, Bj?rn-Ph,Krüger, Aileen,Froese, Alexander,Bork, Nadja I.,Nikolaev, Viacheslav O.,Guse, Andreas H.,Meier, Chris
, (2018/11/25)
Adenine nucleotide (AN) 2nd messengers, such as 3',5'-cyclic adenosine monophosphate (cAMP), are central elements of intracellular signaling, but many details of their underlying processes remain elusive. Like all nucleotides, cyclic nucleotide monophosphates (cNMPs) are net-negatively charged at physiologic pH which limits their applicability in cell-based settings. Thus, many cellular assays rely on sophisticated techniques like microinjection or electroporation. This setup is not feasible for medium- to high-throughput formats, and the mechanic stress that cells are exposed to raises the probability of interfering artefacts or false-positives. Here, we present a short and flexible chemical route yielding membrane-permeable, bio-reversibly masked cNMPs for which we employed the octanoyloxybenzyl (OB) group. We further show hydrolysis studies on chemical stability and enzymatic activation, and present results of real-time assays, where we used cAMP and Ca2+ live cell imaging to demonstrate high permeability and prompt intracellular conversion of some selected masked cNMPs. Based on these results, our novel OB-masked cNMPs constitute valuable precursor-tools for non-invasive studies on intracellular signaling.
