131172-61-7

Basic information

• Product Name: 5-(4-CHLORO-PHENYL)-1H-PYRROLE-2-CARBOXYLIC ACID
• Synonyms: 5-(4-CHLORO-PHENYL)-1H-PYRROLE-2-CARBOXYLIC ACID
• CAS NO: 131172-61-7
• Molecular Formula: C₁₁H₈ClNO₂
• Molecular Weight: 221.64
• Mol File: 131172-61-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(4-CHLORO-PHENYL)-1H-PYRROLE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-CHLORO-PHENYL)-1H-PYRROLE-2-CARBOXYLIC ACID(131172-61-7)
• EPA Substance Registry System: 5-(4-CHLORO-PHENYL)-1H-PYRROLE-2-CARBOXYLIC ACID(131172-61-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 131172-61-7(Hazardous Substances Data)

Usage

Derivative

It is derived from pyrrole.

Functional Groups

Carboxylic acid group ( -\textCOOH ): Located at the 2-position of the pyrrole ring.
Chlorophenyl group ( \textC6\textH4\textCl ): Attached to the 5-position of the pyrrole ring.

Potential Applications

Pharmaceutical Industry: Due to its structural features, it may have applications in drug synthesis.

Reactivity

Interesting compound for further research and development in organic chemistry due to its properties and reactivity.

Upstream product

• 91735-77-2 1-(5-(4-chlorophenyl)-1H-pyrrol-2-yl)-2,2,2-trifluoroethan-1-one 
• 153783-24-5 (S)-5-(4-Chloro-phenyl)-3,4-dihydro-2H-pyrrole-2-carboxylic acid ethyl ester 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 144978-35-8 (S)-ethyl N-tert-butoxycarbonylpyroglutamate 
• 153783-19-8 (S)-2-tert-Butoxycarbonylamino-5-(4-chloro-phenyl)-5-oxo-pentanoic acid ethyl ester 
• 1956-39-4 4-chloroacetophenone oxime 
• 19867-89-1 2-(4-chlorophenyl)-1H-pyrrole 
• 99-91-2 para-chloroacetophenone 
• 106-39-8 bromochlorobenzene 

Downstream Products

• 1017414-83-3 5-(4-chlorophenyl)-1-methyl-1H-pyrrole-2-carboxylic acid 

Relevant articles and documents

Synthesis of 5-Arylpyrrole-2-carboxylic Acids as Key Intermediates for NBD Series HIV-1 Entry Inhibitors

5-Arylpyrrole-2-carboxylic acids are important key intermediates in the synthesis of HIV-1 entry inhibitors (such as NBD-11021 and NBD-14010). Here we present a general method for the synthesis of some 5-arylpyrrole-2-carboxylic acids in three steps starting from pyrrole. By this method, the compounds could be prepared on gram scale and without chromatographic purification.

General method for the synthesis of 5-arylpyrrole-2-carboxylic acids

5-Arylpyrrole-2-carboxylic acids are prepared by DDQ oxidative aromatization of the corresponding ethyl 2-aryl-Δ1-pyrroline-5-carboxylate followed by basic hydrolysis.