131179-09-4

Basic information

• Product Name: 7-Azabicyclo[2.2.1]hept-2-ene-7-carboxylicacid,methylester,syn-(9CI)
• Synonyms: 7-Azabicyclo[2.2.1]hept-2-ene-7-carboxylicacid,methylester,syn-(9CI)
• CAS NO: 131179-09-4
• Molecular Formula: C₈H₁₁NO₂
• Molecular Weight: 0
• Product Categories: CARBOXYLICESTER
• Mol File: 131179-09-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-Azabicyclo[2.2.1]hept-2-ene-7-carboxylicacid,methylester,syn-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Azabicyclo[2.2.1]hept-2-ene-7-carboxylicacid,methylester,syn-(9CI)(131179-09-4)
• EPA Substance Registry System: 7-Azabicyclo[2.2.1]hept-2-ene-7-carboxylicacid,methylester,syn-(9CI)(131179-09-4)

Safety Data

• Hazardous Substances Data: 131179-09-4(Hazardous Substances Data)

Upstream product

• 213745-87-0 2-(Toluene-4-sulfonyl)-3-trimethylsilanyl-7-aza-bicyclo[2.2.1]hept-2-ene-7-carboxylic acid methyl ester 
• 83060-74-6 7-methoxycarbonyl-2-p-toluenesulfonyl-7-azanorbornadiene 
• 4277-63-8 methyl 1H-pyrrole-1-carboxylate 
• 5535-48-8 PVS 
• 131193-46-9 2-(Toluene-4-sulfonyl)-7-aza-bicyclo[2.2.1]hept-2-ene-7-carboxylic acid methyl ester 

Downstream Products

• 55590-24-4 7-Azabicyclo[2.2.1]-hept-2-ene 
• 155322-26-2 dechloro-epibatidine 

Relevant articles and documents

Synthesis and structure-activity data of some new epibatidine analogues

The high-pressure Diels-Alder reaction of N-carbomethoxypyrroles and phenyl vinyl sulfone affords versatile intermediates for the palladium-catalyzed preparation of new epibatidine analogues. Structure-activity relationships of new epibatidine analogues are presented. High affinities of K(i)=0.81 and 2.6nM for the [3H]-cytisine rat brain nicotinic acetylcholine binding sites were found for the 5-pyrimidinyl and the 5-(2-amino)-pyrimidinyl epibatidine analogues, respectively. Copyright (C) 1997 Elsevier Science Ltd.

A Total Synthesis of (+/-)-Epibatidine

A total synthesis of the potent non-opiate analgesic alcaloid epibatidine is described, in which the key step is reductive palladium-catalysed Heck-type coupling.The synthesis is concise (two steps from known compounds), highly convergent, and completely sttereoselective for the desired exo-isomer. - Key Words: Epibatidine, Analgesic, Alkaloid, Palladium-catalysed Coupling

Synthesis of 7-azabicyclo[2.2.1]heptane and 2-oxa-4-azabicyclo[3.3.1]non-3- ene derivatives by base-promoted heterocyclization of alkyl N-(cis(trans)-3, trans(cis)-4-dibromocyclohex-1-yl)carbamates and N-(cis(trans)-3,trans(cis)-4- dibromocyclohex-1-yl)-2

(Chemical Equation Presented) We have studied the base-promoted heterocyclization of alkyl N-(cis(trans)-3,trans(cis)-4-dibromocyclohex-1-yl) carbamates and N-(cis(trans)-3,trans(cis)-4-dibromocyclohex-1-yl)-2,2,2- trifluoroacetamides, investigating the e