155322-26-2Relevant articles and documents
Synthesis and [11C]-radiolabelling of dechloro-epibatidine and 2PABH, two potential radioligands for studying the central nAChRs in vivo
Spang,Patt,Westera,Schubiger
, p. 761 - 771 (2007/10/03)
The two epibatidine (EPB) analogues dechloro-epibatidine (DCl-EPB) and 2PABH were synthesised via a two step reaction starting from N-methoxycarbonyl-7-azabicyclo[2.2.1]heptene. The radiochemical syntheses of [11C]N-methylated derivatives was performed using the classical methylating agent [11C]CH3I in acetonitrile. The radiochemical yield ranged from 5 to 10% (decay corrected from [11C]CH3I) and was fully sufficient for small animal experiments. High specific activities in the range of 140 to 360 GBq/μmol at EOS (end of synthesis) were obtained. The radiosynthesis, semipreparative HPLC, formulation and quality control were completed in an average time of 35 min.