131179-72-1

Basic information

• Product Name: N-(4-FLUOROPHENYL)-2-(4-HYDROXYPHENYL)ACETAMIDE
• Synonyms: N-(4-FLUOROPHENYL)-2-(4-HYDROXYPHENYL)ACETAMIDE
• CAS NO: 131179-72-1
• Molecular Formula: C₁₄H₁₂FNO₂
• Molecular Weight: 245.25
• Mol File: 131179-72-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 139-141°C
• Boiling Point: 488.1°Cat760mmHg
• Flash Point: 249°C
• Appearance: /
• Density: 1.319g/cm³
• Vapor Pressure: 3.77E-10mmHg at 25°C
• Refractive Index: 1.639
• CAS DataBase Reference: N-(4-FLUOROPHENYL)-2-(4-HYDROXYPHENYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-FLUOROPHENYL)-2-(4-HYDROXYPHENYL)ACETAMIDE(131179-72-1)
• EPA Substance Registry System: N-(4-FLUOROPHENYL)-2-(4-HYDROXYPHENYL)ACETAMIDE(131179-72-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 131179-72-1(Hazardous Substances Data)

Usage

General Description

N-(4-Fluorophenyl)-2-(4-hydroxyphenyl)acetamide is a synthetic organic compound distinguished by the presence of amide, aromatic, and halogen elements in its chemical structure. It has a molecular formula of C14H12FNO2 and primarily features fluorophenyl and hydroxyphenyl groups attached to an acetamide backbone. N-(4-FLUOROPHENYL)-2-(4-HYDROXYPHENYL)ACETAMIDE does not have broad public exposure uses in commercial or household products. In scientific research contexts, it may be utilised as a reference compound or synthetic intermediate towards developing other complex molecules. Its properties such as reactivity, potential health effects, or ecological impacts are not well documented, indicating the need for further detailed studies.

InChI:InChI=1/C14H12FNO2/c15-11-3-5-12(6-4-11)16-14(18)9-10-1-7-13(17)8-2-10/h1-8,17H,9H2,(H,16,18)

Upstream product

• 156-38-7 4-hydroxyphenylacetate 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 131179-90-3 2-<4-<<(4-fluoroanilino)carbonyl>methyl>phenoxy>-2-methylpropionic acid 

Relevant articles and documents

Allosteric Modifiers of Hemoglobin. 1. Design, Synthesis, Testing, and Structure-Allosteric Activity Relationship of Novel Hemoglobin Oxygen Affinity Decreasing Agents

Three isomeric series of 2-(aryloxy)-2-methylpropionic acids were prepared and studied for their ability to decrease the oxygen affinity of human hemoglobin A.The isomeric aryloxy groups included 4-methyl>phenoxy, 4-(arylacetamido)phenoxy, and 4-methyl>phenoxy.A total of 20 compounds were synthesized and tested.Structure-activity relationships are presented.Several of the new compounds were found to be strong allosteric effectors of hemoglobin.The two most active compounds are 2-methyl>phenoxy>-2-methylpropionic acid and the corresponding 3,5-dimethyl derivative.The latter two compounds have been compared to other known potent allosteric effectors in the same assay and show greater activity.Both compounds also exhibit a right shift in the oxygen equilibrium curve when incubated with whole blood.The new compounds may be of interest in clinical or biological areas that require or would benefit from a reversal of depleted oxygen supply (i.e., ischemia, stroke, tumor radiotherapy, blood storage, blood substitutes, etc.).They are also structurally related to several marketed antilipidemic agents.