131184-73-1

Basic information

• Product Name: 2-Amino-5-thiazolemethanol
• Synonyms: 5-Thiazolemethanol,2-amino-(9CI);5-Thiazolemethanol, 2-amino;(2-Amino-1,3-thiazol-5-yl)methanol;2-Amino-5-thiazolemethanol;5-(Hydroxymethyl)thiazol-2-ylamine;2-Amino-5-(hydroxymethyl)thiazole;(2-AMinothiazol-5-yl)Methanol;2-Amino-5-(hydroxymethyl)-1,3-thiazole
• CAS NO: 131184-73-1
• Molecular Formula: C₄H₆N₂OS
• Molecular Weight: 130.17
• Product Categories: AMINEPRIMARY
• Mol File: 131184-73-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 340.738 °C at 760 mmHg
• Flash Point: 159.873 °C
• Appearance: /
• Density: 1.475
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.682
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Dichloromethane, Methanol
• PKA: 13.54±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-5-thiazolemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5-thiazolemethanol(131184-73-1)
• EPA Substance Registry System: 2-Amino-5-thiazolemethanol(131184-73-1)

Safety Data

• Hazardous Substances Data: 131184-73-1(Hazardous Substances Data)

Usage

Chemical Properties

2-Amino-5-thiazolemethanol is Yellow Solid

Uses

2-Amino-5-(hydroxymethyl)thiazole is a reactant used in the preparation of imino-quinone methide type intermediates.

InChI:InChI=1/C4H6N2OS/c5-4-6-1-3(2-7)8-4/h1,7H,2H2,(H2,5,6)

Upstream product

• 765-34-4 Glycidaldehyde 
• 32955-21-8 2-amino-thiazole-5-carboxylic acid ethyl ester 
• 1003-61-8 2-aminothiazole-5-carbaldehyde 

Downstream Products

• 1194551-47-7 5-((4-bromophenethoxy)methyl)thiazol-2-amine 
• 1194551-84-2 2-((2-aminothiazol-5-yl)methyl)-4-bromo-3,5-dimethylphenol 
• 1194551-71-7 (S)-3-((2-aminothiazol-5-yl)methyl)-4-benzyloxazolidin-2-one 
• 1194551-63-7 5-((4-fluorophenylsulfonyl)methyl)thiazol-2-amine 
• 1194551-67-1 N-((2-aminothiazol-5-yl)methyl)benzamide 
• 299953-06-3 5-[(4-methoxyphenyl)methyl]thiazol-2-amine 
• 1194551-76-2 2-((2-aminothiazol-5-yl)methyl)-4-chlorophenol 
• 1194551-57-9 N-((2-aminothiazol-5-yl)methyl)-N,4-dimethylbenzenesulfonamide 
• 349481-23-8 (6-(4-fluorophenyl)imidazo[2,1-b]thiazol-2-yI)methanol 
• 1151240-67-3 {2-[({1-[(3,4-dichlorophenyl)methyl]-1H-1,2,3-triazol-4-yl}methyl)amino]-1,3-thiazol-5-yl}methanol 

Relevant articles and documents

Hetero-aromatic compound and its use in medicine

The invention provides a hetero-aromatic compound or a stereisomer, geometric isomer, tautomer, despinner, nitrogen oxide, hydrate, solvate, metabolite, metabolism precursor and pharmaceutically acceptable salt or prodrug thereof, which is used for treating proliferative diseases. The invention also discloses a pharmaceutical composition containing the compound and an application of the compound or pharmaceutical composition thereof in preparation of a medicine for treating proliferative diseases.

PROSTAGLANDIN D SYNTHASE INHIBITORY PIPERIDINE COMPOUNDS

The present invention provides a piperidine compound represented by Formula (I) (wherein X1, X2, X2, A, B and N are as defined in the Description); or a salt thereof.

H2-antagonists: Synthesis and activity of 2-Amino-5-thiazolyl derivatives

2-Amino- and 2-guanidinothiazole derivatives having in position 5 a methylthioalkyl side-chain with urea-equivalent moieties were prepared for comparison with H2-antagonists of cimetidine and tiotidine series. Examination of the pharmacological results obtained from experiments on guinea pig atria and in cat gastric fistula, suggests some general observations about the structure-activity relationship of the compounds synthesized. The activity trend of these products is different from that of H2-imidazole antagonists while it is similar to that of the tiotidine series. Unlike the tiotidine similar compounds, the 2-guanidino-5-thiazolyl derivatives are less potent than the corresponding 2-amino-5-thiazolyl products. The activity of the latter ones is reduced in comparison to that of tiotidine or cimetidine.