1311975-74-2

Upstream product

• 1227610-59-4 trans-1-phenyl-1,2,3,4-tetrahydro-9H-β-carboline-3-carboxylic acid ethyl ester 
• 7479-05-2 L-tryptophan ethyl ester 
• 100-52-7 benzaldehyde 
• 1447959-74-1 trans-ethyl 2-(2-chloroacetyl)-1-phenyl-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylate 
• 100-46-9 benzylamine 
• 13139-14-5 Boc-Trp-OH 
• 88333-03-3 Benzyl isocyanide 

Relevant academic research and scientific papers

Highly stereoselective one-pot construction of trisubstituted tetrahydro-β-carboline-fused diketopiperazines: A synthetic route towards cialis analogues

A facile and efficient synthetic method for the stereoselective preparation of trisubstituted tetrahydro-β-carboline-fused diketopiperazine derivatives is reported. The methodology represents a one-pot four-step reaction, employing the Ugi four-component

Synthesis of Functionalized Diketopiperazines as Cyclotryprostatin and Tryprostatin Analogues

Various ketopiperazines were synthesized as (cyclo)tryprostatin analogues. Construction of the skeleton started with a Pictet-Spengler reaction followed by acylation or alkylation of the piperidine nitrogen and condensation with a primary amine. 2-Chloroacetyl tetrahydro-β-carbolines rearranged towards the corresponding 2-chloro-N-[2-(1H-indol-3-yl)ethyl]acetamide deriv-atives upon treatment with NBS. These compounds were cyclized with primary amines towards the corresponding functionalized diketopiperazines. Georg Thieme Verlag Stuttgart . New York.