131216-60-9

Upstream product

• 141-78-6 ethyl acetate 

Downstream Products

• 131216-55-2 (R)-2-(2,4-Dichloro-phenyl)-3-[1,2,4]triazol-1-yl-propan-1-ol 
• 131320-41-7 (+)-R-1-[2-(2,4-dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl]-1H-1,2,4-triazole 
• 37504-67-9 (αS)-α-(acetoxymethyl)benzeneacetic acid 
• 16202-15-6 (S)-tropic acid 

Relevant academic research and scientific papers

Enzymatic preparation of optically active fungicide intermediates in aqueous and in organic media

Pure stereoisomers of two new triazole and morpholine fungicides have been prepared starting from enzymatically synthesized chiral alcohol intermediates.Two resolution strategies compared are: lipase-catalyzed hydrolysis of corresponding acetates in water and lipase-catalyzed transesterification of alcohols in organic solvents.The antifungal activity of optically pure enantiomers of the synthesized fungicides investigated in vitro and in vivo against a variety of fungi, show an activity ratio (R-form/S-form) up to 400.