1312201-54-9Relevant articles and documents
Structure-based design of novel boronic acid-based inhibitors of autotaxin
Albers, Harald M. H. G.,Hendrickx, Loes J. D.,Van Tol, Rob J. P.,Hausmann, Jens,Perrakis, Anastassis,Ovaa, Huib
, p. 4619 - 4626 (2011/09/14)
Autotaxin (ATX) is a secreted phosphodiesterase that hydrolyzes the abundant phospholipid lysophosphatidylcholine (LPC) to produce lysophosphatidic acid (LPA). The ATX-LPA signaling axis has been implicated in inflammation, fibrosis, and tumor progression