131223-63-7

Upstream product

• 1194-98-5 2,5-Dihydroxybenzaldehyde 
• 109-87-5 Dimethoxymethane 
• 13709-07-4 2,5-bis(methoxymethoxy)benzaldehyde 
• 60-29-7 diethyl ether 
• 107-30-2 chloromethyl methyl ether 
• 13057-17-5 bromethyl methyl ether 

Downstream Products

• 216442-96-5 2-Formyl-4-methoxymethoxyphenyl trifluoromethanesulphonate 
• 142677-35-8 (+/-)-(1S*,2S*,5R*,6S*)-2-(2,6-Dimethoxyphenoxy)-1-hydroxy-6-<2-methoxy-5-(2-methoxyethoxy)phenyl>-3,7-dioxabicyclo<3.3.0>octane 
• 142677-35-8 (+/-)-(1S*,2R*,5R*,6S*)-2-(2,6-Dimethoxyphenoxy)-1-hydroxy-6-<2-methoxy-5-(2-methoxyethoxy)phenyl>-3,7-dioxabicyclo<3.3.0>octane 
• 142706-07-8 (+/-)-(3S*,4R*,1'R*)-4-<1-(tert-Butyldimethylsilyl)oxy-1-(2-methoxy-5-methoxymethoxyphenyl)methyl>-3-hydroxy-3-hydroxymethyldihydro-2(3H)-furanone 
• 142706-07-8 (+/-)-(3S*,4R*,1'S*)-4-<1-(tert-Butyldimethylsilyl)oxy-1-(2-methoxy-5-methoxymethoxyphenyl)methyl>-3-hydroxy-3-hydroxymethyldihydro-2(3H)-furanone 
• 142677-28-9 (+/-)-(3R*,4R*,1'S*)-4-<1-(tert-Butyldimethylsilyl)oxy-1-(2-methoxy-5-methoxymethoxyphenyl)methyl>-3-hydroxymethyl-2(3H)-furanone 
• 142677-28-9 (+/-)-(3R*,4R*,1'R*)-4-<1-(tert-Butyldimethylsilyl)oxy-1-(2-methoxy-5-methoxymethoxyphenyl)methyl>-3-hydroxymethyl-2(3H)-furanone 
• 142677-27-8 (+/-)-(3R*,2R*,1'R*)-2-<1-(tert-Butyldimethylsilyl)oxy-1-(2-methoxy-5-methoxymethoxyphenyl)methyl>-3-vinyl-1,4-butanediol 
• 142677-27-8 (+/-)-(3R*,2R*,1'S*)-2-<1-(tert-Butyldimethylsilyl)oxy-1-(2-methoxy-5-methoxymethoxyphenyl)methyl>-3-vinyl-1,4-butanediol 
• 142677-29-0 (+/-)-(4R*,1'R*)-4-<1-(tert-Butyldimethylsilyl)oxy-1-(2-methoxy-5-methoxymethoxyphenyl)methyl>-3-methylenedihydro-2(3H)-furanone 
• 142677-29-0 (+/-)-(4R*,1'S*)-4-<1-(tert-Butyldimethylsilyl)oxy-1-(2-methoxy-5-methoxymethoxyphenyl)methyl>-3-methylenedihydro-2(3H)-furanone 
• 142677-26-7 (+/-)-(3S*,4R*,1'S*)-3-<1-(tert-Butyldimethylsilyl)oxy-1-(2-methoxy-5-methoxymethoxyphenyl)methyl>-4-vinyldihydro-2(3H)-furanone 
• 142677-26-7 (+/-)-(3S*,4R*,1'R*)-3-<1-(tert-Butyldimethylsilyl)oxy-1-(2-methoxy-5-methoxymethoxyphenyl)methyl>-4-vinyldihydro-2(3H)-furanone 
• 142677-17-6 (+/-)-(3S*,4R*,1'R*)-4-<1-Hydroxy-1-(2-methoxy-5-methoxymethoxyphenyl)methyl>-3-hydroxymethyldihydro-2(3H)-furanone 

Relevant academic research and scientific papers

Chroman-4-ones via microwave-promoted domino Claisen rearrangement-oxa-michael addition: Synthesis of tabchromones A and B

Allyl phenyl ethers with a pendant enone substituent undergo, upon microwave irradiation, a domino sequence of Claisen rearrangement and 6-endo-trig-cyclization to furnish functionalized chroman-4-ones. The natural products tabchromones A and B were synthesized via this method.

Tandem Claisen Rearrangement/6-endo Cyclization Approach to Allylated and Prenylated Chromones

Allyl, dimethylallyl and prenyl ethers derived from o-acylphenols reacted upon microwave irradiation to form C-allylated or -prenylated chromone derivatives, depending on the substitution pattern of the arene and the allyl substituent. The reaction proceeds through a tandem Claisen rearrangement and 6-endo-trig or 6-endo-dig cyclization sequence. For prenyl ethers, the tandem sequence can be extended by a Cope rearrangement to furnish 6-prenylchromones. The method is potentially useful for the synthesis of natural products and drugs.

SEVEN-MEMBERED RING COMPOUND, PRODUCTION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF

A 7-membered heterocyclic compound having the formula (I), or its salt, or a solvate thereof with a chymase inhibitory action and useful for the prevention or treatment of various diseases, in which chymase is involved: a method for producing the same, and a pharmaceutical composition useful for the prevention or treatment of diseases, in which chymase is involved, including the compound of having the formula (I), or its pharmaceutically acceptable salt, or a solvate thereof are provided.

7-MEMBERED RING COMPOUND, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL USE THEREOF

A 7-membered heterocyclic compound having the formula (I), or its salt, or a solvate thereof with a chymase inhibitory action and useful for the prevention or treatment of various diseases, in which chymase is involved: a method for producing the same, and a pharmaceutical composition useful for the prevention or treatment of diseases, in which chymase is involved, including the compound of having the formula (I), or its pharmaceutically acceptable salt, or a solvate thereof are provided.

Triaromatic compounds and pharmaceutical/cosmetic compositions comprised thereof

Novel pharmaceutically/cosmetically-active triaromatic compounds have the structural formula (I): and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular, bone and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.

Synthesis and Insecticidal Activity of Lignan Analogs (1)

Several analogs modifying the 6-methoxy-2-methoxymethyl-3-(3,4-methylenedioxyphenyl)-1,4-benzodioxan-7-yl group of haedoxans were synthesized and their insecticidal activity was examined. 2-(2,6-Dimethoxyphenoxy)-1-hydroxy-6-(2-methoxy-5-methoxyethoxyphen