1312309-82-2

Upstream product

• 100-51-6 benzyl alcohol 
• 1254367-42-4 phenyl 3-(benzyloxy)-2-bromo-6-chloro-5-methylisonicotinate 
• 1254367-43-5 C₂₀H₁₇NO₄ 
• 1254367-41-3 phenyl 5-(benzyloxy)-2-chloro-3-methylisonicotinate 
• 1253799-65-3 phenyl 3-(benzyloxy)-5-methylisonicotinate 
• 1253799-63-1 phenyl 3-(benzyloxy)-5-chloroisonicotinate 
• 1253799-61-9 3-(benzyloxy)-5-chloroisonicotinic acid 
• 1254367-57-1 (4aS,11aR,12aS,13S)-8-bromo-10-chloro-13-(dimethylamino)-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-11a,12,12a,13-tetrahydro-5-hydroxy-3,7-bis(phenylmethoxy)-isoxazolo[5',4':6,7]naphth[2,3-g]-isoquinoline-4,6(4aH,11H)-dione 
• 78-81-9 isobutylamine 
• 1254367-46-8 C₂₀H₁₆ClNO₄ 

Relevant academic research and scientific papers

8-azatetracyclines: Synthesis and evaluation of a novel class of tetracycline antibacterial agents

A novel series of fully synthetic 8-azatetracyclines was prepared and evaluated for antibacterial activity. Compounds were identified that overcome both efflux (tet(K)) and ribosomal protection (tet(M)) tetracycline resistance mechanisms and are active against Gram-positive and Gram-negative organisms. Two compounds were identified that exhibit comparable efficacy to marketed tetracyclines in in vivo models of bacterial infection.