131233-07-3

Basic information

• Product Name: 1-<2-<(3,4-Dimethoxyphenyl)methoxy>phenyl>-2-<(4-methylphenyl)sulphinyl>ethanone
• Synonyms: 1-<2-<(3,4-Dimethoxyphenyl)methoxy>phenyl>-2-<(4-methylphenyl)sulphinyl>ethanone
• CAS NO: 131233-07-3
• Molecular Weight: 424.518
• Mol File: 131233-07-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-<2-<(3,4-Dimethoxyphenyl)methoxy>phenyl>-2-<(4-methylphenyl)sulphinyl>ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-<2-<(3,4-Dimethoxyphenyl)methoxy>phenyl>-2-<(4-methylphenyl)sulphinyl>ethanone(131233-07-3)
• EPA Substance Registry System: 1-<2-<(3,4-Dimethoxyphenyl)methoxy>phenyl>-2-<(4-methylphenyl)sulphinyl>ethanone(131233-07-3)

Safety Data

• Hazardous Substances Data: 131233-07-3(Hazardous Substances Data)

Upstream product

• 7306-46-9 4-chloromethyl-1,2-dimethoxy-benzene 
• 119-36-8 methyl salicylate 
• 934-72-5 Methyl p-tolyl sulfoxide 
• 73119-94-5 Methyl 2-<(3,4-Dimethoxyphenyl)methoxy>benzoate 

Downstream Products

• 108378-98-9 rac-(2S,3S)-2-methyl-3-(toluene-4-sulfonyl)chroman-4-one 
• 108378-98-9 2-methyl-3-(toluene-4-sulfonyl)chroman-4-one 
• 108378-96-7 (2R,3S)-2-Methyl-3-((R)-toluene-4-sulfinyl)-chroman-4-one 
• 108378-96-7 trans-2,3-Dihydro-2-methyl-3-<(4-methylphenyl)sulphinyl>-4H-1-benzopyran-4-one 
• 108378-96-7 cis-2,3-Dihydro-2-methyl-3-<(4-methylphenyl)sulphinyl>-4H-1-benzopyran-4-one 
• 108378-96-7 (2S,3S)-2-Methyl-3-((S)-toluene-4-sulfinyl)-chroman-4-one 
• 108378-93-4 3-<(4-Methylphenyl)sulphinyl>-4H-1-benzopyran-4-one 
• 5751-48-4 2-methylchromone 
• 108378-95-6 1-(2-Hydroxyphenyl)-2-<(4-methylphenyl)sulphinyl>ethanone 

Relevant articles and documents

Conjugate addition to 3-(ptolylsulphinyl)chromone: A route to 2-substituted chromones and chiral substituted chroman-4-ones

3-(p-Tolylsulphinyl)chromone 3a undergoes diastereoselective conjugate addition of lithium dimethylcuprate, producing a mixture of 2-methyl-3-(p-tolylsulphinyl)chroman-4-ones. Heating the mixture to 140°C gives 2-methylchromone in quantitative yield. Desulphurisation of the mixed products from (S)-3a gives (S)-2-methylchroman-4-one with 90% e.e. Chelation of the carbonyl and sulphoxide oxygens during methyl addition accounts for the diastereo selection.