5751-48-4

Basic information

• Product Name: 2-Methylchromone
• Synonyms: 2-Methylchromone;2-Methyl-4H-chroMen-4-one;2-Methyl-4H-1-benzopyran-4-one
• CAS NO: 5751-48-4
• Molecular Formula: C₁₀H₈O₂
• Molecular Weight: 160.1693
• Mol File: 5751-48-4.mol
• Article Data: 125

Chemical Properties

• Melting Point: 72-73 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 249.5°Cat760mmHg
• Flash Point: 108.6°C
• Appearance: /
• Density: 1.185g/cm³
• Vapor Pressure: 0.0228mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Methylchromone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methylchromone(5751-48-4)
• EPA Substance Registry System: 2-Methylchromone(5751-48-4)

Safety Data

• Hazardous Substances Data: 5751-48-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H8O2/c1-7-6-9(11)8-4-2-3-5-10(8)12-7/h2-6H,1H3

Upstream product

• 16636-62-7 1-(2'-hydroxyphenyl)butane-1,3-dione 
• 88912-80-5 4-Diphenylmethylene-2-methyl-4H-1-benzopyran 
• 96237-59-1 dimethyl (E)-3-(2-methoxycarbonylphenoxy)pent-2-enedioate 
• 96237-65-9 dimethyl (E)-3-phenoxypent-2-enedioate 
• 5538-51-2 O-acetylsalicyloyl chloride 
• 118-93-4 o-hydroxyacetophenone 
• 1077-79-8 methyl 2-acetylbenzoate 
• 3739-97-7 (trimethylsilyl)methylenetriphenylphosphorane 
• 129512-44-3 tert-butyldimethylsilyl 2-acetoxybenzoate 
• 7647-01-0 hydrogenchloride 
• 326925-91-1 3-acetyl-chroman-2,4-dione 
• 51751-37-2 2-Methyl-4-oxo-4H-<1>benzopyran-3-carboxylic acid 
• 74555-98-9 ethyl 2-methyl-4-oxo-4H-1-benzopyran-3-carboxylate 
• 147590-72-5 2-methyl-3-methoxychromone 

Downstream Products

• 76576-71-1 3-Chloro-2-methoxy-2-methyl-chroman-4-one 
• 76576-73-3 3-Bromo-2-methoxy-2-methyl-chroman-4-one 
• 130681-19-5 4-<(tert-Butyldimethylsilyl)oxy>-2-methyl-1-benzopyrylium trifluoromethanesulfonate 
• 3780-33-4 2,3-dihydro-2,2-dimethylbenzo[b]pyran-4-one 
• 80212-21-1 (E)-2-[2-(4-methylphenyl)vinyl]-4H-chromen-4-one 
• 77420-45-2 (E)-NN-diethyl-2-<2-(4-oxo-4H-1-benzopyran-2-yl)vinyl>benzamide 
• 54592-00-6 3-(chloromethyl)-2-methyl-4H-chromen-4-one 
• 118450-18-3 dithiosemicarbazone of 1-(2-hydroxyphenyl)-1,3-butanedione 
• 118450-17-2 2-methylchromone thiosemicarbazidone 
• 51138-46-6 3⁽⁵⁾-methyl-5⁽³⁾-(2-hydroxyphenyl)pyrazole 
• 80212-28-8 2-<β-(2-naphthyl)vinyl>-4H-chromen-4-one 
• 51138-47-7 2-methylchromone phenylhydrazone 
• 51138-45-5 1-phenyl-3-methyl-5-(2'-hydroxyphenyl)pyrazole 
• 5464-60-8 N,N'-bis(2-hydroxy(methyl)benzylidene)ethylenediamine 

Relevant articles and documents

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A “turn-on” fluorescent probe with high selectivity and large stokes shift for the detection of hydrogen peroxide and its bioimaging applications

Hydrogen peroxide (H2O2) plays pivotal roles in various biological functions and pharmacological activities. High selectivity and sensitivity remain challenges for fluorescent probes to detection of H2O2 with a large stokes shift. Herein, a new “turn-on” fluorescent probe (DCM-C) was designed based on the mechanism of intramolecular charge transfer (ICT). In PBS buffer (10 mM, pH 7.4, with 20% DMSO, v/v), DCM-C exhibited high selectivity and sensitivity for H2O2 over other interfering analytes with a large stokes shift (187 nm), and the detection limit was as low as 35.5 nM. In addition, the probe was effective for detecting exogenous and endogenous H2O2 in living cells, and identifying stained in cytoplasm. Moreover, the probe has been used successfully for determining H2O2 in zebrafish by fluorescence imaging.

A matrix targeted fluorescent probe to monitor mitochondrial dynamics

Mitochondria are an indispensable organelle for energy production and regulation of cellular metabolism. The structural and functional alterations to mitochondria instigate pathological conditions of cancer, and aging-associated and neurodegenerative disorders. The normal functioning of mitochondria is maintained by quality control mechanisms involving dynamic fission, fusion, biogenesis and mitophagy. Under conditions of mitophagy and neurodegenerative diseases, mitochondria are exposed to different acidic environments and high levels of reactive oxygen species (ROS). Therefore stable molecular tools and methods are required to monitor the pathways linked to mitochondrial dysfunction and disease conditions. Herein, we report a far-red fluorescent probe (Mito-TG) with excellent biocompatibility, biostability, photostability, chemical stability and turn on emission for selective targeting of the mitochondrial matrix in different live cells. The probe was successfully employed for monitoring dynamic processes of mitophagy and amyloid beta (Aβ) induced mitochondrial structural changes.

Near-infrared compound with aggregation-induced emission property as well as preparation method and application thereof

The invention discloses a near-infrared compound with an aggregation-induced emission property as well as a preparation method and application of the near-infrared compound. The near-infrared compoundhas high-brightness far-infrared and near-infrared fluorescence emission characteristics, has aggregation-induced emission and crystallization-induced emission characteristics in a near-infrared region, and has the characteristic of aggregation-induced nonlinear optical effect. The nanocrystal can be used for biological imaging and can be prepared into nanocrystals for living body deep high-resolution multi-photon fluorescence and third harmonic imaging. The material synthesized by the method shows the properties of aggregation-induced emission and crystallization-induced emission, while thetraditional fluorescent dye has the phenomenon of aggregation-induced fluorescence quenching under the condition of high concentration, so that the defects of the traditional fluorescent dye are effectively overcome.