1312338-82-1

Basic information

• Product Name: D-cis-4,5-methanoprolineamide methanesulfonic acid salt
• Synonyms: D-cis-4,5-methanoprolineamide methanesulfonic acid salt
• CAS NO: 1312338-82-1
• Molecular Weight: 222.265
• Mol File: 1312338-82-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: D-cis-4,5-methanoprolineamide methanesulfonic acid salt(CAS DataBase Reference)
• NIST Chemistry Reference: D-cis-4,5-methanoprolineamide methanesulfonic acid salt(1312338-82-1)
• EPA Substance Registry System: D-cis-4,5-methanoprolineamide methanesulfonic acid salt(1312338-82-1)

Safety Data

• Hazardous Substances Data: 1312338-82-1(Hazardous Substances Data)

Upstream product

• 68766-96-1 ethyl (R)-2-pyrrolidone-5-carboxylate 

Downstream Products

• 1564265-95-7 (R)-3-hydroxyadamantylglycine-D-cis-4,5-methanoprolinenitrile 
• 1564265-94-6 (S)-3-hydroxyadamantylglycine-D-cis-4,5-methanoprolinenitrile 
• 1250941-17-3 (lR,3S,5R)-tert-butyl 3-(4-(3-bromophenyl)-lH-imidazol-2-yl)-2-azabicyclo[3.1.0]hexane-2-carboxylate 
• 1250941-14-0 (lR,3S,5R)-3-(2-(3-bromophenyl)-2-oxoethyl) 2-tert-butyl 2-azabicyclo[3.1.0]hexane-2,3-dicarboxylate 
• 197142-33-9 3-hydroxymethyl-2-azabicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester 
• 1180671-56-0 (1R,3S,5R)-tert-butyl 3-(5-(4-bromophenyl)-1H-imidazol-2-yl)-2-azabicyclo[3.1.0]hexane-2-carboxylate 
• 197142-34-0 (1R,3S,5R)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid 

Relevant articles and documents

Synthesis and biological evaluation of all eight stereoisomers of DPP-IV inhibitor saxagliptin

All eight stereoisomers of saxagliptin have been synthesized and evaluated for their inhibitory activity against DPP-IV. It was unambiguously confirmed that the configuration of saxagliptin was critical to potent inhibition of DPP-IV. Docking study was performed to elucidate the configuration-activity relationship of saxagliptin stereoisomers. Tyr662 and Tyr470 have been suggested as the key residues of DPP-IV interacting with the inhibitors. This work provides valuable information for further inhibitor design against DPP-IV.