131235-66-0

Upstream product

• 676345-33-8 (E)-Hex-2-enedioic acid 6-methyl ester 1-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl] ester 
• 591-51-5 phenyllithium 
• 67-56-1 methanol 
• 167304-71-4 (R)-2-Oxo-5-phenyl-cyclopentanecarboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 

Downstream Products

• 64145-51-3 (R)-3-phenylcyclopentanone 

Relevant academic research and scientific papers

3-Substituted and 2,3-Disubstituted Cyclopentanones via an Asymmetric Tandem 1,4-Addition/Dieckmann Cyclization

A new stereoselective method for the synthesis of 3-substituted and 2,3-disubstituted cyclopentanones is described. The key step is the 1, 4-addition of a cuprate to a chilar Michael-acceptor derived from (-)-8-phenylmenthol or the Helmchen auxiliary followed by Dieckmann cyclization of the obtained chiral enolates. The resultant 2,3-cyclopentanones can be transformed after methanolysis and demethoxycarbonylation to the related 3-substituted cyclopentanones.

77. Carbenoid Reactions in Rhodium(II)-Catalyzed Decomposition of Iodonium Ylides

The intermediacy of metallocarbenes in decomposition reactions of iodonium ylides with was established by comparison with reactions of the corresponding diazo compounds.The sensitivity of the RhII-catalyzed intermolecular cyclopropa