1312355-77-3Relevant academic research and scientific papers
Pyridopyrimidinone inhibitors of HIV-1 RNase H
Velthuisen, Emile J.,Johns, Brian A.,Gerondelis, Peter,Chen, Yan,Li, Ming,Mou, Ke,Zhang, Wenwen,Seal, John W.,Hightower, Kendra E.,Miranda, Sonia R.,Brown, Kevin,Leesnitzer, Lisa
, p. 609 - 616 (2014/07/21)
Using a structure based pharmacophore design, a weak inhibitor of RNase H, identified from a small library of two metal binding HIV-1 integrase inhibitors, was optimized for potency and physicochemical properties. This manuscript describes the SAR and in vivo DMPK for the pyridopyrimidinone class of inhibitors.
