1312356-08-3

Upstream product

• 1312356-01-6 2-{[(phenylmethyl)oxy]amino}-3-pyridinecarboxylic acid 
• 1312356-04-9 methyl 2-{[(phenylmethyl)oxy]amino}-3-pyridine carboxylate 
• 1312356-05-0 methyl 2-{[({[4-(methyloxy)phenyl]methyl}amino)carbonyl][(phenylmethyl)oxy]amino}-3-pyridine carboxylate 
• 1312356-06-1 C₂₂H₁₉N₃O₄ 
• 622-33-3 N-benzyloxyamine 
• 446-26-4 methyl 2-fluoro-3-pyridinecarboxylate 
• 3019-71-4 Trichloroacetyl isocyanate 

Downstream Products

• 1312356-11-8 C₂₆H₂₇N₅O₃ 
• 1312356-10-7 4-chloro-1-[(phenylmethyl)oxy]pyrido[2,3-d]pyrimidin-2(1H)-one 
• 1621544-81-7 1-(benzyloxy)-4-((4-fluorobenzyl)amino)pyrido[2,3-d]pyrimidin-2(1H)-one 
• 1312345-12-2 4-([1,1'-biphenyl]-4-ylamino)-1-hydroxypyrido[2,3-d]pyrimidin-2(1H)-one 
• 1312411-65-6 1-hydroxy-4-((4-(pyridin-4-yl)phenyl)amino)pyrido[2,3-d]pyrimidin-2(1H)-one 
• 1312355-77-3 1-hydroxy-4-({[3-(4-morpholinylmethyl)phenyl]methyl}amino)pyrido[2,3-d]pyrimidin-2(1H)-one 

Relevant academic research and scientific papers

1-Hydroxypyrido[2,3-d]pyrimidin-2(1H)-ones as novel selective HIV integrase inhibitors obtained via privileged substructure-based compound libraries

A small library containing 3-hydroxyquinazoline-2,4(1H,3H)-dione and 1-hydroxypyrido[2,3-d]pyrimidin-2(1H)-one scaffolds was obtained via the copper(I)-catalyzed azidealkyne cycloaddition (CuAAC) reaction and evaluated for their anti-HIV activity in MT-4

4-(1,2,3-triazole substituted anilino)-pyridinopyrimidinones derivative and preparation method and application thereof

The invention provides a 4-(1,2,3-triazole substituted anilino)-pyridinopyrimidinones derivative. The structure of the 4-(1,2,3-triazole substituted anilino)-pyridinopyrimidinones derivative is shown in the general formula I, wherein 1,2,3-triazole loop is aniline ortho-substituted and meta-substituted, and R is 4-fluorobenzyl or 4-methylbenzyl or phenethyl or phenylpropyl or 1-naphthyl or anilino acyl methyl or 4-fluoro- anilino acyl methyl or 4-fluoro-phenacyl or 4-trifluoromethyl-anilino acyl methyl. The invention further relates to a preparation method of the 4-(1,2,3-triazole substituted anilino)-pyridinopyrimidinones derivative and application of the 4-(1,2,3-triazole substituted anilino)-pyridinopyrimidinones derivative as an HIV inhibitor for preparing anti-AIDS medicine.

Pyridopyrimidinone inhibitors of HIV-1 RNase H

Using a structure based pharmacophore design, a weak inhibitor of RNase H, identified from a small library of two metal binding HIV-1 integrase inhibitors, was optimized for potency and physicochemical properties. This manuscript describes the SAR and in vivo DMPK for the pyridopyrimidinone class of inhibitors.