131237-48-4Relevant academic research and scientific papers
A Rapid Injection NMR Study of the Reaction of Organolithium Reagents with Esters, Amides, and Ketones
Plessel, Kristin N.,Jones, Amanda C.,Wherritt, Daniel J.,Maksymowicz, Rebecca M.,Poweleit, Eric T.,Reich, Hans J.
, p. 2310 - 2313 (2015)
Unexpectedly high rates of reaction between alkyllithium reagents and amides, compared to esters and ketones, were observed by Rapid Inject NMR and competition experiments. Spectroscopic investigations with 4-fluorophenyllithium (ArLi, mixture of monomer and dimer in THF) and a benzoate ester identified two reactive intermediates, a homodimer of the tetrahedral intermediate, stable below -100°C, and a mixed dimer with ArLi. Direct formation of dimers suggested that the ArLi dimer may be the reactive aggregate rather than the usually more reactive monomer. In contrast, RINMR experiments with ketones demonstrated that the ArLi monomer was the reactive species. (Chemical Equation Presented).
X-ray Studies of Sterically Congested Diphenylethane Derivatives. Substitutent Effect on Carbon-Carbon Bond Length
Maslak, Przemyslaw,Narvaez, Javier N.,Parvez, Masood
, p. 602 - 607 (2007/10/02)
Crystal structures of several sterically strained diphenylethane derivatives have been obtained.The central C-C bond lengths in these compounds span 1.623 (7) to 1.649 (4) Angstroem but are independent of substitution on the phenyl ring.
