17318-03-5

Basic information

• Product Name: 3-FLUOROPHENYLMAGNESIUM BROMIDE
• Synonyms: 3-FLUOROPHENYLMAGNESIUM BROMIDE;3-FLUOROPHENYLMAGNESIUM BROMIDE, 0.5M SOLU TION IN TETRAHYDROFURAN;3-FLUOROPHENYLMAGNESIUM BROMIDE, 1.0M SO;3-Fluorophenylmagnesium bromide, 1M in MeTHF;3-Fluorophenylmagnesium bromide solution 1.0 in THF;3-Fluorophenylmagnesium bromide solution 0.5 in THF;3-Fluorophenylmagnesium bromide, 1M solution in THF, AcroSeal;3-FluorophenylMagnesiuM broMide solution 1.0 M in THF
• CAS NO: 17318-03-5
• Molecular Formula: C₆H₄BrFMg
• Molecular Weight: 199.3
• Product Categories: Aryl;Grignard Reagents;Organometallic Reagents;Grignard Reagent
• Mol File: 17318-03-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 65 °C
• Flash Point: <1 °F
• Appearance: /
• Density: 1.024 g/mL at 25 °C
• Storage Temp.: 2-8°C
• Water Solubility: It reacts violently with water.
• Sensitive: Air & Moisture Sensitive
• CAS DataBase Reference: 3-FLUOROPHENYLMAGNESIUM BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUOROPHENYLMAGNESIUM BROMIDE(17318-03-5)
• EPA Substance Registry System: 3-FLUOROPHENYLMAGNESIUM BROMIDE(17318-03-5)

Safety Data

• Hazard Codes: F,C
• Statements: 11-14-19-34-22-40-37
• Safety Statements: 16-26-33-36/37/39-45-7/8-43
• RIDADR: UN 2924 3/PG 2
• WGK Germany: 1
• HazardClass: 3
• Hazardous Substances Data: 17318-03-5(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to yellow to orange to brown liquid

Uses

Different sources of media describe the Uses of 17318-03-5 differently. You can refer to the following data:
1. 3-Fluorophenylmagnesium bromide is used as a Grignard reagent in greener solvent, 2-methyltetrahydrofuran (2-MeTHF).
2. 3-Fluorophenylmagnesium bromide is a Grignard reagent that can be used in:The preparation of 4-substituted quinazolines by reacting with 2-methylaminobenzonitriles.The synthesis of radiolabeled TrkB/C-targeting kinase inhibitor for positron emission tomography (PET) imaging applications.Cu-catalyzed carbometalation of substituted cyclopropenes.

InChI:InChI=1/C6H4F.BrH.Mg/c7-6-4-2-1-3-5-6;;/h1-2,4-5H;1H;/q;;+1/p-1/rC6H4BrFMg/c7-9-6-3-1-2-5(8)4-6/h1-4H

Upstream product

• 1073-06-9 3-fluorobromobenzene 
• 75716-82-4 imidazol-1-yl-oxo-acetic acid ethyl ester 

Downstream Products

• 35929-40-9 3-Diethylamino-1,1-bis-(3-fluoro-phenyl)-2-methyl-propan-1-ol 
• 36029-76-2 α-(Chlordifluormethyl)-α-(trifluormethyl)-m-fluor-benzylalkohol 
• 27374-61-4 1-(3-fluorophenyl)naphthalene 
• 131237-48-4 5-(3-fluorophenyl)nonan-5-ol 
• 122243-29-2 1,1,1-Trifluoro-2-(3-fluoro-phenyl)-propan-2-ol 
• 2396-30-7 m-Fluorphenyl-heptafluorpropyl-keton 
• 402-63-1 1-(3-fluorophenyl)ethanol 
• 396-64-5 3,3'-difluoro-biphenyl 
• 445040-03-9 (3-fluorophenyl)(2-(4-methylthiophenyl)phenyl)methan-1-ol 
• 445038-54-0 (3-fluorophenyl)(6-(4-methylthiophenyl)(2H-benzo[d]1,3-dioxolan-5-yl))methan-1-ol 
• 131029-54-4 bis-(3-fluorophenyl)acetaldehyde 
• 33756-24-0 tris(3-flourophenyl)bismuthine 
• 174018-64-5 2-(3-fluorophenyl)naphthalene 
• 1002916-54-2 [8-(3-Fluoro-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-dimethyl-amine hydrochloride 

Relevant articles and documents

COMPOSITIONS AND METHODS OF USING THE SAME FOR TREATMENT OF NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE

The present disclosure is directed to adenine analogs, methods of making adenine analogs, and methods of treating disorders associated with PINK1 kinase activity including, but not limited to, neurodegenerative diseases, mitochondrial diseases, fibrosis,

Chromium(II)-Catalyzed Diastereoselective and Chemoselective Csp2-Csp3 Cross-Couplings Using Organomagnesium Reagents

A simple protocol for performing chromium-catalyzed highly diastereoselective alkylations of arylmagnesium halides with cyclohexyl iodides at ambient temperature has been developed. Furthermore, this ligand-free CrCl2 enables efficient electrophilic alkenylations of primary, secondary, and tetiary alkylmagnesium halides with readily available alkenyl acetates. Moreover, this chemoselective C-C coupling reaction with stereodefined alkenyl acetates proceeds in a stereoretentive fashion. A wide range of functional groups on alkyl iodides and alkenyl acetates are well tolerated, thus furnishing functionalized Csp2-Csp3 coupling products in good yields and high diastereoselectivity. Detailed mechanistic studies suggest that the in situ generated low-valent chromium(I) species might be the active catalyst for these Csp2-Csp3 cross-couplings.

Novel tetranuclear triarylantimony(v) complexes with (±)-mandelic acid ligands: Synthesis, characterization, in vitro cytotoxicity and DNA binding properties

Four novel tetranuclear organoantimony(v) complexes [R3SbL] 4, in which LH = (±)-mandelic acid and R = phenyl (1), 4-fluorophenyl (2), 3-fluorophenyl (3), 3,4,5-trifluorophenyl (4), were synthesized and characterized. The complexes displayed rapid, low micromolar in vitro cytotoxicity against a range of epithelial tumour cells and efficient CT-DNA binding.