1312443-45-0

Basic information

• Product Name: (4R,5S)-5-((1S,2R)-2-amino-1-hydroxy-3-phenylpropyl)-4-benzyloxazolidin-2-one
• Synonyms: (4R,5S)-5-((1S,2R)-2-amino-1-hydroxy-3-phenylpropyl)-4-benzyloxazolidin-2-one
• CAS NO: 1312443-45-0
• Molecular Weight: 326.395
• Mol File: 1312443-45-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4R,5S)-5-((1S,2R)-2-amino-1-hydroxy-3-phenylpropyl)-4-benzyloxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5S)-5-((1S,2R)-2-amino-1-hydroxy-3-phenylpropyl)-4-benzyloxazolidin-2-one(1312443-45-0)
• EPA Substance Registry System: (4R,5S)-5-((1S,2R)-2-amino-1-hydroxy-3-phenylpropyl)-4-benzyloxazolidin-2-one(1312443-45-0)

Safety Data

• Hazardous Substances Data: 1312443-45-0(Hazardous Substances Data)

Upstream product

• 153223-10-0 (2R,3S,4S,5R)-2,5-bis[N-(benzyloxycarbonyl)amino]-1,6-diphenyl-3,4-hexanediol 
• 63219-70-5 N-(benzyloxycarbonyl)-D-phenylalaninal 
• 58917-85-4 N-(benzyloxycarbonyl)-D-phenylalaninol 
• 201230-82-2 carbon monoxide 
• 219586-75-1 (2R,3S,4S,5R)-2,5-diamino-1,6-diphenyl-3,4-hexanediol 

Relevant articles and documents

Carbonylation of functionalized diamine diols to cyclic ureas: Application to derivatives of DMP 450

Synthesis of the cyclic urea core structure of the HIV protease inhibitor DMP 450 has been achieved via W(CO)6/I2-catalyzed carbonylation of diamine intermediates. Carbonylations of related functionalized diamines to derivatives of the DMP 450 core structure were also examined. Selected diamine diol substrates could be converted to the cyclic urea core structure by catalytic carbonylation without protection of the diol functionality.